Twf2 - twinfilin actin binding protein 2 Gene

Also Known as Ptk9l; Ptk9r; A6-related

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23999

Summary

Enables actin monomer binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in barbed-end actin filament capping and sequestering of actin monomers. Located in several cellular components, including lamellipodium; myofibril; and stereocilium. Is expressed in several structures, including ear; early embryo; genitourinary system; nervous system; and respiratory system. Orthologous to human TWF2 (twinfilin actin binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Twf2 Products (1)

mRNA Protein Name
NM_011876.3 NP_036006.1 twinfilin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin monomer binding IDA
IDA: Inferred from direct assay
12807912 MGI
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
12807912 MGI
Biological Process GO Annotation Evidence References Source
involved in barbed-end actin filament capping IDA
IDA: Inferred from direct assay
18837697 MGI
involved in negative regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
12807912 MGI
involved in sequestering of actin monomers IDA
IDA: Inferred from direct assay
18837697 MGI
Cellular Component GO Annotation Evidence References Source
located in filopodium IDA
IDA: Inferred from direct assay
12807912 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
12807912 MGI
located in myofibril IDA
IDA: Inferred from direct assay
18837697 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12807912 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
19955359 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

twinfilin-2

  • PTK9 protein typrotein tyrosine kinase 9-like (A6-related protein)

  • mA6RP

  • protein tyrosine kinase 9 related protein

  • protein tyrosine kinase 9-like (A6-related protein)

  • twinfilin, actin-binding protein, homolog 2

  • twinfilin-1-like protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15280 TWF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Twf2 NCBI NCBI:11344