TWF2 - twinfilin actin binding protein 2 Gene

Also Known as A6r; A6RP; PTK9L; MSTP011

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11344

About TWF2

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:52,228,612-52,239,158 (from NCBI)

This gene has 18 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 28.1), heart (RPKM 27.1) and 25 other tissues.

Summary

The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]

TWF2 Products (1)

mRNA	Protein	Name
NM_007284.4	NP_009215.1	twinfilin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10406962	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	10406962	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to growth factor stimulus	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	17910947	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA
located in growth cone	IDA IDA: Inferred from direct assay	17910947	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TWF2 Protein Structure

Cofilin_ADF

0
100
200
300
349 a.a.

Protein Preferred Names	Protein Names
twinfilin-2	A6-related protein

TWF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TWF2	Q6IBS0	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	TWF2	Q6IBS0	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Monkeypox	Monkeypox Virus Infections

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15280	TWF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TWF2	MGD	MGI:1346078
Canis familiaris	TWF2	VGNC	VGNC:49952
Bos taurus	TWF2	VGNC	VGNC:107006
Rattus norvegicus	TWF2	RGD	RGD:1591460
Others	TWF2	NCBI