Rasgrp3 - RAS, guanyl releasing protein 3 Gene

Also Known as Gm327

Species: Mus musculus

Gene Type: protein coding
Gene ID: 240168

Summary

Enables guanyl-nucleotide exchange factor activity; kinase binding activity; and small GTPase binding activity. Acts upstream of or within Ras protein signal transduction and regulation of GTPase activity. Located in perinuclear region of cytoplasm. Part of guanyl-nucleotide exchange factor complex. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RASGRP3 (Ras guanyl releasing protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Rasgrp3 Products (4)

mRNA Protein Name
NM_001166493.2 NP_001159965.1 ras guanyl-releasing protein 3
NM_001360103.1 NP_001347032.1 ras guanyl-releasing protein 3
NM_001411230.1 NP_001398159.1 ras guanyl-releasing protein 3
NM_207246.4 NP_997129.1 ras guanyl-releasing protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
15545601 MGI
enables kinase binding IPI
IPI: Inferred from physical interaction
15894621 MGI
enables small GTPase binding IDA
IDA: Inferred from direct assay
15545601 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
15894621 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Ras protein signal transduction IDA
IDA: Inferred from direct assay
15545601 MGI
acts upstream of or within regulation of GTPase activity IDA
IDA: Inferred from direct assay
15545601 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15545601 MGI
part of guanyl-nucleotide exchange factor complex IDA
IDA: Inferred from direct assay
15894621 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15894621 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras guanyl-releasing protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11695 RASGRP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123977 RasGRP3 ligand 1 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rasgrp3 NCBI NCBI:25780