Kif20b - kinesin family member 20B Gene

Also Known as MPP1; 33cex; magoo; Mphosph1; C330014J10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 240641

Summary

Predicted to enable several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including positive regulation of mitotic cytokinetic process; positive regulation of neuron migration; and protein localization to microtubule. Acts upstream of or within neural tube closure; regulation of establishment of protein localization; and regulation of neuron migration. Located in several cellular components, including midbody; perinuclear region of cytoplasm; and spindle midzone. Is expressed in cerebral cortex marginal layer; cerebral cortex ventricular layer; cortical plate; and cortical subplate. Used to study microcephaly. Orthologous to human KIF20B (Kinesin family member 20B). [provided by Alliance of Genome Resources, Apr 2022]

Kif20b Products (2)

mRNA	Protein	Name
NM_001362434.1	NP_001349363.1	kinesin-like protein KIF20B isoform 2
NM_183046.2	NP_898867.1	kinesin-like protein KIF20B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23864681	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	15755804	MGI
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	23864681	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	24173802	MGI
involved in positive regulation of intracellular protein transport	IMP IMP: Inferred from mutant phenotype	23864681	MGI
involved in positive regulation of mitotic cytokinetic process	IMP IMP: Inferred from mutant phenotype	24173802	MGI
involved in positive regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	23864681	MGI
involved in protein localization to microtubule	IMP IMP: Inferred from mutant phenotype	23864681	MGI
acts upstream of or within regulation of establishment of cell polarity	IGI IGI: Inferred from genetic interaction	23864681	MGI
involved in regulation of establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	23864681	MGI
acts upstream of or within regulation of establishment of protein localization	IDA IDA: Inferred from direct assay	23864681	MGI
acts upstream of or within regulation of neuron migration	IGI IGI: Inferred from genetic interaction	23864681	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	23864681	MGI
located in midbody	IDA IDA: Inferred from direct assay	23864681	MGI
located in nucleus	IDA IDA: Inferred from direct assay	24173802	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	23864681	MGI
located in spindle midzone	IDA IDA: Inferred from direct assay	24173802	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
kinesin-like protein KIF20B	M-phase phosphoprotein 1 N-6 kinesin kinesin-related motor interacting with PIN1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07273	KIF20B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kif20b	NCBI	NCBI:9585