KIF20B - kinesin family member 20B Gene

Also Known as CT90; MPP1; KRMP1; MPP-1; MPHOSPH1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9585

About KIF20B

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,701,590-89,774,934 (from NCBI)

This gene has 4 transcripts (splice variants) and 269 orthologues. Broad expression in testis (RPKM 5.3), lymph node (RPKM 5.3) and 24 other tissues.

Summary

Enables several functions, including WW domain binding activity; plus-end-directed microtubule motor activity; and protein homodimerization activity. Involved in positive regulation of cell population proliferation and positive regulation of cytokinesis. Located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

KIF20B Products (3)

mRNA Protein Name
NM_001284259.2 NP_001271188.1 kinesin-like protein KIF20B isoform 1
NM_001382506.1 NP_001369435.1 kinesin-like protein KIF20B isoform 3
NM_016195.4 NP_057279.2 kinesin-like protein KIF20B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
11470801 GOA
enables WW domain binding IPI
IPI: Inferred from physical interaction
11470801 GOA
enables microtubule binding IDA
IDA: Inferred from direct assay
12740395 GOA
enables plus-end-directed microtubule motor activity IDA
IDA: Inferred from direct assay
12740395 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17409436 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
11470801 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12740395 GOA
involved in positive regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
12740395 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
11470801 GOA
located in contractile ring IDA
IDA: Inferred from direct assay
17409436 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
8885239 GOA
located in midbody IDA
IDA: Inferred from direct assay
12740395 GOA
located in mitotic spindle midzone IDA
IDA: Inferred from direct assay
12740395 GOA
located in mitotic spindle pole IDA
IDA: Inferred from direct assay
11470801 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
11470801 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
11470801 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12740395 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF20B Protein Structure

Kinesin

Kinesin: Kinesin motor domain (64 - 479)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1820 a.a.
Protein Preferred Names Protein Names

kinesin-like protein KIF20B

  • M-phase phosphoprotein 1

Related Diseases

Diseases Alias
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Primary Autosomal Recessive Microcephaly

  • Autosomal Recessive Primary Microcephaly

  • Mcph

  • True Microcephaly

  • Microcephalia Vera

  • Microcephaly Vera

  • Microcephaly Primary Hereditary

  • Microcephaly, Primary, Autosomal Recessive

  • Primary Microcephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07273 KIF20B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KIF20B MGD MGI:2444576
Canis familiaris KIF20B VGNC VGNC:42395
Rattus norvegicus KIF20B RGD RGD:1308497
Bos taurus KIF20B VGNC VGNC:107297
Macaca mulatta KIF20B VGNC VGNC:74035
Others KIF20B NCBI