Gdf6 - growth differentiation factor 6 Gene

Also Known as BMP13; GDF16; BMP-13

Species: Mus musculus

Gene Type: protein coding
Gene ID: 242316

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mice lacking a functional copy of this gene exhibit joint and skeletal defects. [provided by RefSeq, Sep 2016]

Gdf6 Products (1)

mRNA Protein Name
NM_013526.1 NP_038554.1 growth/differentiation factor 6 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16049014 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
16049014 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: Inferred from genetic interaction
16049014 MGI
involved in BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
26774823 MGI
acts upstream of or within positive effect cell migration involved in metanephros development IMP
IMP: Inferred from mutant phenotype
32737436 MGI
acts upstream of or within positive effect epithelial cell migration IMP
IMP: Inferred from mutant phenotype
32737436 MGI
involved in fat cell differentiation IMP
IMP: Inferred from mutant phenotype
26774823 MGI
involved in metanephros development IMP
IMP: Inferred from mutant phenotype
32737436 MGI
involved in positive regulation of SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
26774823 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
9786991 MGI
involved in positive regulation of p38MAPK cascade IMP
IMP: Inferred from mutant phenotype
26774823 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth/differentiation factor 6

  • GDF-6

  • bone morphogenetic protein 13

  • growth/differentiation factor 16

Recombinant Gdf6 Proteins

Cat. No. Product Name Accession Purity
HY-P79333 BMP-13/GDF-6 Protein, Mouse P43028 (T335-R454) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05356 GDF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174775 Human BMPR1A mRNA / Unkown
HY-RS21347 Gdf6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27866 Gdf6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gdf6 NCBI NCBI:392255