Grip2 - glutamate receptor interacting protein 2 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 243547

Summary

Predicted to enable glutamate receptor binding activity and protein C-terminus binding activity. Involved in neurotransmitter receptor transport, endosome to postsynaptic membrane and vesicle-mediated transport in synapse. Acts upstream of or within Notch signaling pathway; artery smooth muscle contraction; and positive regulation of blood pressure. Is active in glutamatergic synapse. Is expressed in diencephalon lateral wall mantle layer; olfactory cortex mantle layer; and tongue. Orthologous to human GRIP2 (glutamate receptor interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Grip2 Products (3)

mRNA	Protein	Name
NM_001159507.2	NP_001152979.1	glutamate receptor-interacting protein 2 isoform 1
NM_001411663.1	NP_001398592.1	glutamate receptor-interacting protein 2 isoform 2
NM_001411664.1	NP_001398593.1	glutamate receptor-interacting protein 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14730302	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	23117660	MGI
acts upstream of or within artery smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	23117660	MGI
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA IDA: Inferred from direct assay	20956289	MGI
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IEP IEP: Inferred from expression pattern	20956289	MGI
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	20956289	MGI
acts upstream of or within positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	23117660	MGI
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	20956289	MGI
involved in vesicle-mediated transport in synapse	IEP IEP: Inferred from expression pattern	20956289	MGI
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	20956289	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20956289	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	20956289	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20956289	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
glutamate receptor-interacting protein 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05810	GRIP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grip2	NCBI	NCBI:80852