Ano2 - anoctamin 2 Gene

Also Known as Tmem16b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 243634

Summary

Enables identical protein binding activity and intracellular calcium activated Chloride Channel activity. Acts upstream of or within chloride transport. Located in non-motile cilium and plasma membrane. Is expressed in dorsal root ganglion; epidermis; medulla oblongata basal plate mantle layer; olfactory epithelium; and spinal cord mantle layer. Orthologous to human ANO2 (anoctamin 2). [provided by Alliance of Genome Resources, Apr 2022]

Ano2 Products (3)

mRNA Protein Name
NM_001364562.1 NP_001351491.1 anoctamin-2 isoform 2
NM_001364563.1 NP_001351492.1 anoctamin-2 isoform 3
NM_153589.2 NP_705817.2 anoctamin-2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
23576756 MGI
enables intracellularly calcium-gated chloride channel activity IDA
IDA: Inferred from direct assay
19474308 MGI
enables intracellularly calcium-gated chloride channel activity IMP
IMP: Inferred from mutant phenotype
21516098 MGI
NOT enables phospholipid scramblase activity IDA
IDA: Inferred from direct assay
23532839 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19474308 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within chloride transport IDA
IDA: Inferred from direct assay
20056604 MGI
acts upstream of or within chloride transport IMP
IMP: Inferred from mutant phenotype
21516098 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: Inferred from direct assay
23532839 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
21516098 MGI
Cellular Component GO Annotation Evidence Références Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19474308 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
21516098 MGI
located in non-motile cilium IDA
IDA: Inferred from direct assay
21516098 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
19474308 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
19474308 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

anoctamin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-146320 ANO1-IN-1 Inhibitor 99.57% Unkown
HY-146321 ANO1-IN-2 Inhibitor / Unkown
HY-RS00742 ANO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22103 Ano2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28624 Ano2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ano2 NCBI NCBI:57101