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Tsku - tsukushi, small leucine rich proteoglycan Gene

Also Known as Tsk; E2ig4; Lrrc54; 9530051K01Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 244152

Summary

Enables transforming growth factor beta binding activity. Involved in several processes, including Cholesterol efflux; Cholesterol homeostasis; and nervous system development. Acts upstream of or within several processes, including ciliary body morphogenesis; negative regulation of Wnt signaling pathway; and telencephalon development. Located in extracellular space. Is expressed in embryo and olfactory epithelium. Orthologous to human TSKU (tsukushi, small leucine rich proteoglycan). [provided by Alliance of Genome Resources, Apr 2022]

Tsku Products (4)

mRNA	Protein	Name
NM_001024619.3	NP_001019790.1	tsukushi precursor
NM_001168539.1	NP_001162011.1	tsukushi precursor
NM_001168540.1	NP_001162012.1	tsukushi precursor
NM_001168541.1	NP_001162013.1	tsukushi precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21856951	MGI
enables transforming growth factor beta binding	IPI IPI: Inferred from physical interaction	22995554	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anterior commissure morphogenesis	IMP IMP: Inferred from mutant phenotype	21055390	MGI
involved in anterior commissure morphogenesis	IMP IMP: Inferred from mutant phenotype	23206892	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	21856951	MGI
involved in cholesterol efflux	IMP IMP: Inferred from mutant phenotype	31391339	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	31391339	MGI
involved in cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	31391339	MGI
acts upstream of or within ciliary body morphogenesis	IMP IMP: Inferred from mutant phenotype	21856951	MGI
acts upstream of or within corpus callosum morphogenesis	IMP IMP: Inferred from mutant phenotype	21055390	MGI
NOT involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	31767170	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	31535079	MGI
involved in hippocampus development	IMP IMP: Inferred from mutant phenotype	31983064	MGI
involved in inner ear receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	32127020	MGI
acts upstream of or within lateral ventricle development	IMP IMP: Inferred from mutant phenotype	21055390	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	21856951	MGI
involved in negative regulation of myofibroblast differentiation	IMP IMP: Inferred from mutant phenotype	25159578	MGI
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	23206892	MGI
involved in negative regulation of transforming growth factor beta1 production	IMP IMP: Inferred from mutant phenotype	25159578	MGI
involved in positive regulation of hair cycle	IMP IMP: Inferred from mutant phenotype	22995554	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21856951	MGI
involved in wound healing	IMP IMP: Inferred from mutant phenotype	25159578	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	21856951	MGI
NOT located in extracellular space	IMP IMP: Inferred from mutant phenotype	31767170	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tsukushi tsukushin	leucine rich repeat containing 54 leucine-rich repeat-containing protein 54

Protein Preferred Names

Protein Names

tsukushi

tsukushin

leucine rich repeat containing 54
leucine-rich repeat-containing protein 54

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15152	TSKU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tsku	NCBI	NCBI:25987