TSKU - tsukushi, small leucine rich proteoglycan Gene

Homo sapiens

Also known as TSK; E2IG4; LRRC54

Gene ID: 25987 | Gene type: protein coding

About TSKU

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:76,782,280-76,798,144 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and 22 paralogues. Broad expression in liver (RPKM 39.4), fat (RPKM 26.7) and 20 other tissues.

Summary

Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in several processes, including animal organ development; Cholesterol efflux; and Cholesterol homeostasis. Predicted to act upstream of or within several processes, including ciliary body morphogenesis; negative regulation of Wnt signaling pathway; and telencephalon development. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

TSKU Products(5)

mRNA	Protein	Name
NM_001258210.2	NP_001245139.1	tsukushi isoform b precursor
NM_001318477.2	NP_001305406.1	tsukushi isoform a precursor
NM_001318478.2	NP_001305407.1	tsukushi isoform b precursor
NM_001318479.2	NP_001305408.1	tsukushi isoform b precursor
NM_015516.4	NP_056331.2	tsukushi isoform b precursor

TSKU Protein Structure

LRR_8

LRR_1

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

tsukushi

E2-induced gene 4 protein

Related Diseases

Diseases

Alias

Epilepsy, Idiopathic Generalized 4

EIG4	Epilepsy, Idiopathic Generalized, Susceptibility To 4
Idiopathic Generalized Epilepsy 4	Epilepsy, Idiopathic Generalized, Susceptibility To, 4
Epilepsy, Idiopathic Generalized Locus On Chromosome 10	Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 10

Barre-Lieou Syndrome

Cervicocranial Syndrome

Posterior Cervical Sympathetic Syndrome

Scheuermann Disease

Scheuermann'S Disease	Spinal Osteochondrosis
Juvenile Osteochondrosis Of Spine	Familial Scheuermann Disease
Familial Scheuermann Juvenile Kyphosis	Familial Spinal Osteochondrosis
Scheuermann Juvenile Kyphosis	Juvenile Osteochondritis Of The Spine
Juvenile Osteochondrosis Of Scheurermann	Scheuermann'S Kyphosis
Sherman'S Disease	Juvenile Kyphosis
Scheuermann Kyphosis	[X]Spinal Osteochondrosis, Unspecified

N Syndrome

NSX	Intellectual Disability, Malformations, Chromosome Breakage, And Development Of T-Cell Leukemia

Bardet-Biedl Syndrome 10

BBS10	Bardet-Biedl Syndrome
Bbs	Bardet-Biedl Syndrome, Type 10

Gallbladder Benign Neoplasm

Myasthenic Syndrome, Congenital, 21, Presynaptic

Congenital Myasthenic Syndrome 21	CMS21
Congenital Myasthenic Syndrome 21, Presynaptic

Gallbladder Adenoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15152	TSKU Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TSKU	RGD	RGD:1359311
Bos taurus	TSKU	VGNC	VGNC:54896
Canis familiaris	TSKU	VGNC	VGNC:52857
Mus musculus	TSKU	MGD	MGI:2443855
Macaca mulatta	TSKU	VGNC	VGNC:79746