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Lipc - lipase C, hepatic type Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24538

Summary

Enables several functions, including heparan sulfate proteoglycan binding activity; Lipase activity; and lipoprotein particle binding activity. Involved in several processes, including glycerolipid metabolic process; low-density lipoprotein particle clearance; and plasma lipoprotein particle remodeling. Located in several cellular components, including cell surface; endosome; and microvillus. Used to study several diseases, including end stage renal disease; hepatitis; hyperinsulinism; obesity; and protein-energy malnutrition. Biomarker of ischemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Orthologous to human LIPC (Lipase C, hepatic type). [provided by Alliance of Genome Resources, Apr 2022]

Lipc Products (1)

mRNA	Protein	Name
NM_012597.2	NP_036729.2	hepatic triacylglycerol lipase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables acetylesterase activity	IDA IDA: Inferred from direct assay	1940628	RGD
enables acyltransferase activity	IDA IDA: Inferred from direct assay	9048565	RGD
enables apolipoprotein binding	IDA IDA: Inferred from direct assay	9685400	RGD
enables apolipoprotein binding	IPI IPI: Inferred from physical interaction	9685400	RGD
enables chylomicron binding	IDA IDA: Inferred from direct assay	9685400	RGD
enables heparan sulfate proteoglycan binding	IMP IMP: Inferred from mutant phenotype	15102889	RGD
enables heparin binding	IDA IDA: Inferred from direct assay	10681410	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	9540793	RGD
enables lipid binding	IDA IDA: Inferred from direct assay	1865764	RGD
enables low-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	8071607	RGD
enables lysophospholipase activity	IDA IDA: Inferred from direct assay	1531641	RGD
enables monoacylglycerol lipase activity	IDA IDA: Inferred from direct assay	6696938	RGD
enables phospholipase A1 activity	IDA IDA: Inferred from direct assay	1531641	RGD
enables triacylglycerol lipase activity	IDA IDA: Inferred from direct assay	1531641	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in aflatoxin metabolic process	IEP IEP: Inferred from expression pattern	28959666	RGD
involved in cellular response to hormone stimulus	IEP IEP: Inferred from expression pattern	12234100	RGD
involved in chylomicron remnant clearance	IDA IDA: Inferred from direct assay	8192680	RGD
involved in chylomicron remodeling	IDA IDA: Inferred from direct assay	7897313	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	9728079	RGD
involved in developmental growth	IEP IEP: Inferred from expression pattern	1391269	RGD
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	10734075	RGD
involved in glycerophospholipid catabolic process	IDA IDA: Inferred from direct assay	9048565	RGD
involved in heparan sulfate proteoglycan biosynthetic process	IDA IDA: Inferred from direct assay	15102889	RGD
involved in high-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	8157689	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	11004003	RGD
involved in low-density lipoprotein particle clearance	IDA IDA: Inferred from direct assay	8071607	RGD
involved in low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	8071607	RGD
involved in neutral lipid catabolic process	IDA IDA: Inferred from direct assay	1865764	RGD
involved in phosphatidic acid metabolic process	IDA IDA: Inferred from direct assay	2223857	RGD
involved in phosphatidylcholine metabolic process	IDA IDA: Inferred from direct assay	2223857	RGD
involved in phosphatidylethanolamine metabolic process	IDA IDA: Inferred from direct assay	2223857	RGD
involved in phosphatidylserine metabolic process	IDA IDA: Inferred from direct assay	2223857	RGD
involved in regulation of plasma lipoprotein particle levels	IMP IMP: Inferred from mutant phenotype	9822677	RGD
involved in response to acetate	IEP IEP: Inferred from expression pattern	11427199	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	19212806	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	9480878	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	15744060	RGD
involved in response to copper ion	IEP IEP: Inferred from expression pattern	3420106	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	2086700	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	15271879	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	8510508	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15271879	RGD
involved in response to lipid	IEP IEP: Inferred from expression pattern	17709442	RGD
involved in response to magnesium ion	IEP IEP: Inferred from expression pattern	2046484	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	19165521	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	9721028	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	16546477	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	8322779	RGD
involved in triglyceride metabolic process	IDA IDA: Inferred from direct assay	10734075	RGD
involved in very-low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	6791934	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	384999	RGD
located in early endosome	IDA IDA: Inferred from direct assay	14701798	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	18691644	RGD
located in late endosome	IDA IDA: Inferred from direct assay	14701798	RGD
located in microvillus	IDA IDA: Inferred from direct assay	9020876	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
hepatic triacylglycerol lipase	HL hepatic lipase lipase member C lipase, hepatic lysophospholipase phospholipase A1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07686	LIPC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lipc	NCBI	NCBI:3990