2. Academic Validation
  3. Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes

Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes

  • Biochem J. 1994 May 1;299 ( Pt 3)(Pt 3):889-94. doi: 10.1042/bj2990889.
P Diard 1,  M I Malewiak,  D Lagrange,  S Griglio
Affiliations

Affiliation

  • 1 Laboratoire de Physiopathologie de la Nutrition, Inserm U177, Institut des Cordeliers, Paris, France.
PMID: 8192680 DOI: 10.1042/bj2990889
Abstract

Active and heat-inactivated hepatic Lipase stimulated to a statistically comparable extent the uptake of chylomicron remnant-like particles by isolated rat hepatocytes by 3-fold and 2.3-fold respectively and, likewise, their binding to hepatic plasma membranes by 5-fold and 4-fold respectively. Hepatic Lipase may facilitate uptake of these particles, not only as a lipolytic enzyme, but also as a ligand anchored to extracellular glycosaminoglycans.

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