Ankrd27 - ankyrin repeat domain 27 (VPS9 domain) Gene

Also Known as Varp; D330003H11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 245886

Summary

Enables SNARE binding activity and small GTPase binding activity. Involved in endosome to melanosome transport; neuron projection morphogenesis; and positive regulation of dendrite morphogenesis. Located in melanosome; neuron projection; and transport vesicle. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and stomach. Human ortholog(s) of this gene implicated in eosinophilic esophagitis. Orthologous to human ANKRD27 (ankyrin repeat domain 27). [provided by Alliance of Genome Resources, Apr 2022]

Ankrd27 Products (3)

mRNA Protein Name
NM_001358876.1 NP_001345805.1 ankyrin repeat domain-containing protein 27 isoform 3
NM_145633.3 NP_663608.3 ankyrin repeat domain-containing protein 27 isoform 1
NM_178263.3 NP_839994.1 ankyrin repeat domain-containing protein 27 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IDA
IDA: Inferred from direct assay
21187829 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18477474 MGI
enables small GTPase binding IDA
IDA: Inferred from direct assay
19403694 MGI
Biological Process GO Annotation Evidence References Source
involved in endosome to melanosome transport IDA
IDA: Inferred from direct assay
21187829 MGI
involved in neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
19745841 MGI
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
22171327 MGI
Cellular Component GO Annotation Evidence References Source
located in melanosome IDA
IDA: Inferred from direct assay
19403694 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
19745841 MGI
located in transport vesicle IDA
IDA: Inferred from direct assay
19745841 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ankyrin repeat domain-containing protein 27

  • VPS9 domain-containing protein

  • VPS9-ankyrin repeat-containing protein

  • VPS9-ankyrin-repeat protein

  • mFLJ00040 protein

Ankrd27 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ankrd27 Q3UMR0 Rab38 Mus musculus Q8QZZ8
Confocal
18477474
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00720 ANKRD27 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ankrd27 NCBI NCBI:84079