Ngef - neuronal guanine nucleotide exchange factor Gene

Rattus norvegicus

Also known as Besh3

Gene ID: 246217 | Gene type: protein coding

About Ngef

Summary

Predicted to enable Ephrin Receptor binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; Ephrin Receptor signaling pathway; and negative regulation of dendritic spine morphogenesis. Predicted to be located in cytoplasm; growth cone; and membrane. Predicted to be active in glutamatergic synapse. Orthologous to human NGEF (neuronal guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Apr 2022]

Ngef Products(1)

mRNA	Protein	Name
NM_001136241.1	NP_001129713.1	ephexin-1

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
is active in postsynapse	IDA IDA: Inferred from direct assay	17143272	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ephexin-1

brain-enriched SH3-domain protein Besh3

eph-interacting exchange protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09276	NGEF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ngef	NCBI	NCBI:25791

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