NGEF - neuronal guanine nucleotide exchange factor Gene

Also Known as EPHEXIN; ARHGEF27

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25791

About NGEF

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:232,878,701-233,013,256 (from NCBI)

This gene has 9 transcripts (splice variants), 200 orthologues and 6 paralogues. Biased expression in brain (RPKM 32.1), duodenum (RPKM 14.9) and 8 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; Ephrin Receptor signaling pathway; and negative regulation of dendritic spine morphogenesis. Predicted to be located in cytosol. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]

NGEF Products (2)

mRNA Protein Name
NM_001114090.2 NP_001107562.1 ephexin-1 isoform 2
NM_019850.3 NP_062824.2 ephexin-1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity EXP
EXP: Inferred from Experiment
15848799 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NGEF Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (278 - 456)

SH3_1

SH3_1: SH3 domain (621 - 665)

  • 0
  • 200
  • 400
  • 600
  • 710 a.a.
Protein Preferred Names Protein Names

ephexin-1

  • eph-interacting exchange protein

NGEF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NGEF Q8N5V2 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
NGEF Q8N5V2 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
NGEF Q8N5V2 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
NGEF Q8N5V2 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
Intra
NGEF Q8N5V2 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
Intra
NGEF Q8N5V2 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
Intra
NGEF Q8N5V2 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
NGEF Q8N5V2 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
NGEF Q8N5V2 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
NGEF Q8N5V2 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
NGEF Q8N5V2 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
NGEF Q8N5V2 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
NGEF Q8N5V2 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
NGEF Q8N5V2 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
NGEF Q8N5V2 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
NGEF Q8N5V2 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
NGEF Q8N5V2 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
NGEF Q8N5V2 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
NGEF Q8N5V2 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
NGEF Q8N5V2 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
NGEF Q8N5V2 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia

  • HH6

  • Kallmann Syndrome 6

  • Kal6

  • Hypogonadotropic Hypogonadism, Type 6 With/Without Anosmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09276 NGEF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NGEF MGD MGI:1858414
Rattus norvegicus NGEF RGD RGD:1309055
Felis catus NGEF VGNC VGNC:80292
Bos taurus NGEF VGNC VGNC:32060
Macaca mulatta NGEF VGNC VGNC:75345
Canis familiaris NGEF VGNC VGNC:43795
Others NGEF NCBI