NGEF - neuronal guanine nucleotide exchange factor Gene

Homo sapiens

Also known as EPHEXIN; ARHGEF27

Gene ID: 25791 | Gene type: protein coding

About NGEF

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:232,878,701-233,013,256 (from NCBI)

This gene has 9 transcripts (splice variants), 200 orthologues and 6 paralogues. Biased expression in brain (RPKM 32.1), duodenum (RPKM 14.9) and 8 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; Ephrin Receptor signaling pathway; and negative regulation of dendritic spine morphogenesis. Predicted to be located in cytosol. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]

NGEF Products(2)

mRNA	Protein	Name
NM_001114090.2	NP_001107562.1	ephexin-1 isoform 2
NM_019850.3	NP_062824.2	ephexin-1 isoform 1

NGEF Protein Structure

RhoGEF

SH3_1

0
200
400
600
710 a.a.

Protein Preferred Names

Protein Names

ephexin-1

eph-interacting exchange protein

Related Diseases

Diseases

Alias

Hypogonadotropic Hypogonadism 6 With Or Without Anosmia

HH6	Kallmann Syndrome 6
Kal6	Hypogonadotropic Hypogonadism, Type 6 With/Without Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09276	NGEF Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NGEF	MGD	MGI:1858414
Rattus norvegicus	NGEF	RGD	RGD:1309055
Felis catus	NGEF	VGNC	VGNC:80292
Bos taurus	NGEF	VGNC	VGNC:32060
Macaca mulatta	NGEF	VGNC	VGNC:75345
Canis familiaris	NGEF	VGNC	VGNC:43795