Arhgap4 - Rho GTPase activating protein 4 Gene

Rattus norvegicus

Gene ID: 246249 | Gene type: protein coding

About Arhgap4

Summary

Enables GTPase activator activity. Involved in negative regulation of axon extension and negative regulation of fibroblast migration. Located in cytoplasm and growth cone. Colocalizes with Golgi apparatus and microtubule. Orthologous to human ARHGAP4 (Rho GTPase activating protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Arhgap4 Products(1)

mRNA	Protein	Name
NM_144740.3	NP_653341.2	rho GTPase-activating protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	12414125	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of axon extension	IMP IMP: Inferred from mutant phenotype	17804252	RGD
involved in negative regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	17804252	RGD
involved in nervous system development	IEP IEP: Inferred from expression pattern	12414125	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in growth cone	IDA IDA: Inferred from direct assay	17804252	RGD
located in microtubule	IDA IDA: Inferred from direct assay	12414125	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rho GTPase-activating protein 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00935	ARHGAP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arhgap4	NCBI	NCBI:393

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