Arhgap4 - Rho GTPase activating protein 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 246249

Summary

Enables GTPase activator activity. Involved in negative regulation of axon extension and negative regulation of fibroblast migration. Located in cytoplasm and growth cone. Colocalizes with Golgi apparatus and microtubule. Orthologous to human ARHGAP4 (Rho GTPase activating protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Arhgap4 Products (1)

mRNA Protein Name
NM_144740.3 NP_653341.2 rho GTPase-activating protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
12414125 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of axon extension IMP
IMP: Inferred from mutant phenotype
17804252 RGD
involved in negative regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
17804252 RGD
involved in nervous system development IEP
IEP: Inferred from expression pattern
12414125 RGD
Cellular Component GO Annotation Evidence References Source
located in growth cone IDA
IDA: Inferred from direct assay
17804252 RGD
located in microtubule IDA
IDA: Inferred from direct assay
12414125 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho GTPase-activating protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00935 ARHGAP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arhgap4 NCBI NCBI:393