country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

ARHGAP4 - Rho GTPase activating protein 4 Gene

Also Known as C1; RGC1; p115; SrGAP4; RhoGAP4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 393

About ARHGAP4

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,907,378-153,926,264 (from NCBI)

This gene has 25 transcripts (splice variants), 248 orthologues and 5 paralogues. Broad expression in spleen (RPKM 47.8), bone marrow (RPKM 45.7) and 16 other tissues.

Summary

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the Ras superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

ARHGAP4 Products (2)

mRNA	Protein	Name
NM_001164741.2	NP_001158213.1	rho GTPase-activating protein 4 isoform 1
NM_001666.5	NP_001657.3	rho GTPase-activating protein 4 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	26365803	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16417406	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP4 Protein Structure

FCH

RhoGAP

SH3_1

0
200
400
600
800
946 a.a.

Protein Preferred Names	Protein Names
rho GTPase-activating protein 4	Rho-GAP hematopoietic protein C1

Related Diseases

Diseases	Alias
Nephrogenic Diabetes Insipidus	Vasopressin-Resistant Diabetes Insipidus Diabetes Insipidus, Nephrogenic Diabetes Insipidus Nephrogenic Congenital Nephrogenic Diabetes Insipidus Adh Resistant Diabetes Insipidus Diabetes Insipidus Nephrogenic X-Linked Diabetes Insipidus Nephrogenic Type 1 Adh-Resistant Diabetes Insipidus Diabetes Insipidus Renalis Ndi Renal Diabetes Insipidus Familial Nephrogenic Diabetes Antidiuretic-Hormone-Resistant Diabetes Insipidus Adiuretin-Resistant Diabetes Insipidus Ndi - [Nephrogenic Diabetes Insipidus] Diabetes Tenuifluus Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus Hereditary Nephrogenic Diabetes Insipidus Familial Nephrogenic Diabetes Insipidus Primary Nephrogenic Diabetes Insipidus
Diabetes Insipidus
X-Linked Nephrogenic Diabetes Insipidus	Nephrogenic Diabetes Insipidus Type 1 Doid:0081060

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00935	ARHGAP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARHGAP4	MGD	MGI:2159577
Rattus norvegicus	ARHGAP4	RGD	RGD:628901
Felis catus	ARHGAP4	VGNC	VGNC:68113
Canis familiaris	ARHGAP4	VGNC	VGNC:38063
Bos taurus	ARHGAP4	VGNC	VGNC:26095
Macaca mulatta	ARHGAP4	VGNC	VGNC:70007
Others	ARHGAP4	NCBI