Zdhhc2 - zinc finger DHHC-type palmitoyltransferase 2 Gene

Rattus norvegicus

Also known as srec; DHHC2

Gene ID: 246326 | Gene type: protein coding

About Zdhhc2

Summary

Predicted to enable protein homodimerization activity and protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including positive regulation of protein localization to membrane; protein localization to cell periphery; and regulation of synaptic plasticity. Located in postsynaptic density. Orthologous to human ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Zdhhc2 Products(1)

mRNA	Protein	Name
NM_145096.3	NP_659564.3	palmitoyltransferase ZDHHC2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptidyl-L-cysteine S-palmitoylation	IMP IMP: Inferred from mutant phenotype	19596852	RGD
involved in positive regulation of AMPA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	19596852	RGD
involved in positive regulation of endosome to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	25589740	RGD
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	25589740	RGD
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	21343290	RGD
involved in protein localization to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	25589740	RGD
involved in regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	19596852	RGD
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping	EXP EXP: Inferred from Experiment	19596852	RGD
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping	IDA IDA: Inferred from direct assay	19596852	RGD
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping	IEP IEP: Inferred from expression pattern	19596852	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	19596852	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19596852	RGD
is active in postsynaptic density	EXP EXP: Inferred from Experiment	19596852	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	19596852	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	19596852	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

palmitoyltransferase ZDHHC2

DHHC-2	acyltransferase ZDHHC2
membrane-associated DHHC2 zinc finger protein	rec
small rec	zinc finger DHHC domain-containing protein 2
zinc finger, DHHC domain containing 2	zinc finger, DHHC-type containing 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16019	ZDHHC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zdhhc2	NCBI	NCBI:51201

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