ZDHHC2 - zinc finger DHHC-type palmitoyltransferase 2 Gene

Also Known as DHHC2; ZNF372

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51201

About ZDHHC2

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,156,482-17,224,799 (from NCBI)

This gene has 4 transcripts (splice variants), 210 orthologues and 17 paralogues. Ubiquitous expression in thyroid (RPKM 18.6), adrenal (RPKM 10.6) and 24 other tissues.

Summary

Enables protein homodimerization activity and protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; regulation of protein catabolic process; and regulation of protein localization to plasma membrane. Located in Golgi apparatus and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZDHHC2 Products (3)

mRNA	Protein	Name
NM_001362988.2	NP_001349917.1	palmitoyltransferase ZDHHC2 isoform 2
NM_001362989.2	NP_001349918.1	palmitoyltransferase ZDHHC2 isoform 3
NM_016353.5	NP_057437.1	palmitoyltransferase ZDHHC2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables palmitoyltransferase activity	IDA IDA: Inferred from direct assay	23034182	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	23793055	GOA
enables protein-cysteine S-palmitoyltransferase activity	IDA IDA: Inferred from direct assay	23793055	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in peptidyl-L-cysteine S-palmitoylation	IDA IDA: Inferred from direct assay	23793055	GOA
involved in peptidyl-L-cysteine S-palmitoylation	IMP IMP: Inferred from mutant phenotype	18296695	GOA
involved in protein localization to membrane raft	IMP IMP: Inferred from mutant phenotype	25589740	GOA
involved in protein palmitoylation	IDA IDA: Inferred from direct assay	23034182	GOA
involved in regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	18508921	GOA
involved in regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	18508921	GOA
involved in regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	18296695	GOA
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	25589740	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16647879	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16647879	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	22034844	GOA
is active in postsynaptic recycling endosome	IMP IMP: Inferred from mutant phenotype	25589740	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC2 Protein Structure

DHHC

0
100
200
300
367 a.a.

Protein Preferred Names	Protein Names
palmitoyltransferase ZDHHC2	DHHC-2

Related Diseases

Diseases	Alias
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever
Arthrogryposis, Distal, Type 2a	Freeman-Sheldon Syndrome Craniocarpotarsal Dystrophy Craniocarpotarsal Dysplasia DA2A Whistling Face-Windmill Vane Hand Syndrome Fss Distal Arthrogryposis Type 2a Whistling Face Syndrome Freeman-Burian Syndrome Arthrogryposis Distal Type 2a Distal Arthrogryposis, Type 2a Fbs Arthrogryposis, Distal, 2a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16019	ZDHHC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZDHHC2	MGD	MGI:1923452
Macaca mulatta	ZDHHC2	VGNC	VGNC:79142
Bos taurus	ZDHHC2	VGNC	VGNC:37135
Rattus norvegicus	ZDHHC2	RGD	RGD:628681
Felis catus	ZDHHC2	VGNC	VGNC:67209
Others	ZDHHC2	NCBI