Slc10a1 - solute carrier family 10 member 1 Gene

Also Known as Ntcp; Ntcp1; SBACT

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24777

Summary

Enables bile acid:sodium symporter activity. Involved in several processes, including bile acid and bile salt transport; bile acid signaling pathway; and response to 17alpha-ethynylestradiol. Located in basolateral plasma membrane. Biomarker of alcoholic hepatitis; cholestasis; and obesity. Orthologous to human SLC10A1 (solute carrier family 10 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc10a1 Products (1)

mRNA Protein Name
NM_017047.2 NP_058743.1 hepatic sodium/bile acid cotransporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables bile acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
15297262 RGD
enables bile acid:sodium symporter activity IDA
IDA: Inferred from direct assay
1961729 RGD
Biological Process GO Annotation Evidence References Source
involved in bile acid and bile salt transport IDA
IDA: Inferred from direct assay
1961729 RGD
involved in bile acid and bile salt transport IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
27090119 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
27090119 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25612518 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
27939985 RGD
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15297262 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatic sodium/bile acid cotransporter

  • NA-dependent cholate transporting protein

  • Na(+)/bile acid cotransporter

  • Na(+)/taurocholate transport protein

  • sodium-dependent bile acid cotransporter

  • sodium-dependent taurocholate cotransporting polypeptide

  • sodium/bile acid cotransporter

  • sodium/taur

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12985 SLC10A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22028 Slc10a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc10a1 NCBI NCBI:6554