2. Gene
  3. Slc10a1 - solute carrier family 10 member 1 Gene

Slc10a1 - solute carrier family 10 member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Ntcp; Ntcp1; SBACT

Gene ID: 24777 | Gene type: protein coding

About Slc10a1

Summary

Enables bile acid:sodium symporter activity. Involved in several processes, including bile acid and bile salt transport; bile acid signaling pathway; and response to 17alpha-ethynylestradiol. Located in basolateral plasma membrane. Biomarker of alcoholic hepatitis; cholestasis; and obesity. Orthologous to human SLC10A1 (solute carrier family 10 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc10a1 Products(1)

mRNA Protein Name
NM_017047.2 NP_058743.1 hepatic sodium/bile acid cotransporter
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables bile acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
15297262 RGD
enables bile acid:sodium symporter activity IDA
IDA: Inferred from direct assay
1961729 RGD
Biological Process GO Annotation Evidence Reference Source
involved in bile acid and bile salt transport IDA
IDA: Inferred from direct assay
1961729 RGD
involved in bile acid and bile salt transport IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
27090119 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
27090119 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25612518 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
27939985 RGD
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15297262 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatic sodium/bile acid cotransporter

NA-dependent cholate transporting protein

Na(+)/bile acid cotransporter

Na(+)/taurocholate transport protein

sodium-dependent bile acid cotransporter

sodium-dependent taurocholate cotransporting polypeptide

sodium/bile acid cotransporter

sodium/taur

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12985 SLC10A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22028 Slc10a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc10a1 NCBI NCBI:6554