Slc2a1 - solute carrier family 2 member 1 Gene

Also Known as GTG1; Gtg3; GLUTB; Glut1; RATGTG1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24778

About Slc2a1

Primary_assembly 5: 132,717,196-132,745,416 forward strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 374 orthologues, 12 paralogues and is associated with 52 phenotypes. Biased expression in Brain (RPKM 185.1), Kidney (RPKM 121.2) and 9 other tissues.

Summary

Enables several functions, including D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and kinase binding activity. Involved in several processes, including cellular hyperosmotic response; cellular response to mechanical stimulus; and dehydroascorbic acid transport. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Colocalizes with sarcolemma. Biomarker of hypertension; hypothyroidism; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in brain disease (multiple); carbohydrate metabolic disorder; myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a1 Products (1)

mRNA	Protein	Name
NM_138827.2	NP_620182.1	solute carrier family 2, facilitated glucose transporter member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	2211693	RGD
enables dehydroascorbic acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	18668520	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	16419038	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10562431	RGD
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	17064664	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in D-glucose import	IMP IMP: Inferred from mutant phenotype	31709908	RGD
involved in D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	2211693	RGD
involved in cellular hyperosmotic response	IEP IEP: Inferred from expression pattern	11546675	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19918242	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	16581179	RGD
involved in dehydroascorbic acid transport	IDA IDA: Inferred from direct assay	9228080	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	21744335	RGD
involved in response to Thyroglobulin triiodothyronine	IEP IEP: Inferred from expression pattern	16581179	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	29676955	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	12399425	RGD
involved in xenobiotic transport	IDA IDA: Inferred from direct assay	17064664	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Z disc	IDA IDA: Inferred from direct assay	8214053	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	18619525	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	18619525	RGD
located in caveola	IDA IDA: Inferred from direct assay	16419038	RGD
located in cell-cell junction	IDA IDA: Inferred from direct assay	17090404	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	18668520	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	8214053	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	18668520	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	8214053	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc2a1 Protein Structure

MFS_GLUT_Class1

0
100
200
300
400
492 a.a.

Protein Preferred Names	Protein Names
solute carrier family 2, facilitated glucose transporter member 1	GLUT-1 Solute carrier family 2 a 1 (facilitated glucose transporter) brain glucose transporter type 1, erythrocyte/brain solute carrier family 2 (facilitated glucose transporter), member 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13157	SLC2A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13158	Slc2a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13159	Slc2a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180874	SLC2A1 modulator-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc2a1	NCBI	NCBI:6513