Slc4a2 - solute carrier family 4 member 2 Gene

Rattus norvegicus

Also known as Ae2; Aep2

Gene ID: 24780 | Gene type: protein coding

About Slc4a2

Summary

Enables enzyme binding activity. Involved in digestive tract development; regulation of intracellular pH; and spermatogenesis. Located in apical plasma membrane and basolateral plasma membrane. Biomarker of autosomal recessive polycystic kidney disease and prediabetes syndrome. Orthologous to human SLC4A2 (solute carrier family 4 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a2 Products(1)

mRNA	Protein	Name
NM_017048.2	NP_058744.1	anion exchange protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chloride:bicarbonate antiporter activity	IDA IDA: Inferred from direct assay	2371270	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	17652430	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in digestive tract development	IEP IEP: Inferred from expression pattern	8770049	RGD
involved in regulation of intracellular pH	IMP IMP: Inferred from mutant phenotype	16440368	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	10491633	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	22310983	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	10600827	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

anion exchange protein 2

AE 2	AE2 Cl-/HCO3-exchanger, variant AE2b
B3RP-2	Solute carrier family 4, member 2, anion exchange protein 2
anion exchanger 2	band 3-related protein 2
non-erythroid band 3-like protein	solute carrier family 4 (anion exchanger), member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13268	SLC4A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc4a2	NCBI	NCBI:6522

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