Myo5a - myosin VA Gene

Rattus norvegicus

Also known as Dop; Myh12

Gene ID: 25017 | Gene type: protein coding

About Myo5a

Summary

Enables several functions, including ATP binding activity; ATP-dependent protein binding activity; and syntaxin-1 binding activity. Involved in several processes, including cytoskeleton-dependent intracellular transport; positive regulation of cytochrome-c oxidase activity; and regulation of secretion by cell. Acts upstream of or within pigmentation. Located in several cellular components, including cytoplasmic vesicle; dendrite; and neuronal cell body. Part of actomyosin, Myosin complex part and ribonucleoprotein complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic actin Cytoskeleton. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (Myosin VA). [provided by Alliance of Genome Resources, Apr 2022]

Myo5a Products(1)

mRNA	Protein	Name
NM_022178.2	NP_071514.2	unconventional myosin-Va

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	16030255	RGD
enables ATP-dependent protein binding	IPI IPI: Inferred from physical interaction	16030255	RGD
enables SNARE binding	IPI IPI: Inferred from physical interaction	16030255	RGD
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	16030255	RGD
enables cytoskeletal motor activity	IMP IMP: Inferred from mutant phenotype	16190983	RGD
enables microfilament motor activity	IDA IDA: Inferred from direct assay	16030255	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19103256	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25456499	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16030255	RGD
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	16030255	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament-based movement	IDA IDA: Inferred from direct assay	16030255	RGD
involved in axo-dendritic protein transport	IMP IMP: Inferred from mutant phenotype	24637809	RGD
involved in dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	29217155	RGD
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	29217155	RGD
involved in negative regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	22639889	RGD
involved in negative regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	27771352	RGD
acts upstream of or within pigmentation	IMP IMP: Inferred from mutant phenotype	10920234	RGD
involved in positive regulation of cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	24478457	RGD
involved in positive regulation of cytochrome-c oxidase activity	IMP IMP: Inferred from mutant phenotype	29217155	RGD
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	24508725	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	24790701	RGD
involved in protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	11470781	RGD
involved in reactive gliosis	IMP IMP: Inferred from mutant phenotype	22639889	RGD
involved in regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	16030255	RGD
involved in secretory granule localization	IDA IDA: Inferred from direct assay	12615975	RGD
involved in secretory granule localization	IMP IMP: Inferred from mutant phenotype	16190983	RGD
involved in vesicle transport along actin filament	IMP IMP: Inferred from mutant phenotype	11470781	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	18311135	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	18311135	RGD
part of actomyosin, myosin complex part	IDA IDA: Inferred from direct assay	16030255	RGD
located in axon	IDA IDA: Inferred from direct assay	11977091	RGD
located in dendrite	IDA IDA: Inferred from direct assay	25456499	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18311135	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18311135	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	11977091	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	18311135	RGD
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	18311135	RGD
is active in postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	18311135	RGD
is active in postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	18311135	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	25456499	RGD
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	24272908	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	12615975	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	16030255	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

unconventional myosin-Va

dilute myosin heavy chain, non-muscle	dilute-opisthotonus
myosin 5a	myosin-Va

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08946	MYO5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myo5a	NCBI	NCBI:4644

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