Myo5a - myosin VA Gene

Also Known as Dop; Myh12

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25017

Summary

Enables several functions, including ATP binding activity; ATP-dependent protein binding activity; and syntaxin-1 binding activity. Involved in several processes, including cytoskeleton-dependent intracellular transport; positive regulation of cytochrome-c oxidase activity; and regulation of secretion by cell. Acts upstream of or within pigmentation. Located in several cellular components, including cytoplasmic vesicle; dendrite; and neuronal cell body. Part of actomyosin, Myosin complex part and ribonucleoprotein complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic actin Cytoskeleton. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (Myosin VA). [provided by Alliance of Genome Resources, Apr 2022]

Myo5a Products (1)

mRNA Protein Name
NM_022178.2 NP_071514.2 unconventional myosin-Va

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
16030255 RGD
enables ATP-dependent protein binding IPI
IPI: Inferred from physical interaction
16030255 RGD
enables SNARE binding IPI
IPI: Inferred from physical interaction
16030255 RGD
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
16030255 RGD
enables cytoskeletal motor activity IMP
IMP: Inferred from mutant phenotype
16190983 RGD
enables microfilament motor activity IDA
IDA: Inferred from direct assay
16030255 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19103256 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
25456499 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
16030255 RGD
enables syntaxin-1 binding IPI
IPI: Inferred from physical interaction
16030255 RGD
Biological Process GO Annotation Evidence References Source
involved in actin filament-based movement IDA
IDA: Inferred from direct assay
16030255 RGD
involved in axo-dendritic protein transport IMP
IMP: Inferred from mutant phenotype
24637809 RGD
involved in dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
29217155 RGD
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
29217155 RGD
involved in negative regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
22639889 RGD
involved in negative regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
27771352 RGD
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
10920234 RGD
involved in positive regulation of cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
24478457 RGD
involved in positive regulation of cytochrome-c oxidase activity IMP
IMP: Inferred from mutant phenotype
29217155 RGD
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
24508725 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
24790701 RGD
involved in protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
11470781 RGD
involved in reactive gliosis IMP
IMP: Inferred from mutant phenotype
22639889 RGD
involved in regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
16030255 RGD
involved in secretory granule localization IDA
IDA: Inferred from direct assay
12615975 RGD
involved in secretory granule localization IMP
IMP: Inferred from mutant phenotype
16190983 RGD
involved in vesicle transport along actin filament IMP
IMP: Inferred from mutant phenotype
11470781 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
18311135 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
18311135 RGD
part of actomyosin, myosin complex part IDA
IDA: Inferred from direct assay
16030255 RGD
located in axon IDA
IDA: Inferred from direct assay
11977091 RGD
located in dendrite IDA
IDA: Inferred from direct assay
25456499 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18311135 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
18311135 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11977091 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
18311135 RGD
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
18311135 RGD
is active in postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
18311135 RGD
is active in postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
18311135 RGD
located in recycling endosome IDA
IDA: Inferred from direct assay
25456499 RGD
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
24272908 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
12615975 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
16030255 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

unconventional myosin-Va

  • dilute myosin heavy chain, non-muscle

  • dilute-opisthotonus

  • myosin 5a

  • myosin-Va

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08946 MYO5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myo5a NCBI NCBI:4644