Aanat - aralkylamine N-acetyltransferase Gene

Also Known as Nat4; AA-NAT

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25120

Summary

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. [provided by RefSeq, Feb 2014]

Aanat Products (1)

mRNA Protein Name
NM_012818.2 NP_036950.1 serotonin N-acetyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 14-3-3 protein binding IDA
IDA: Inferred from direct assay
11427721 RGD
enables aralkylamine N-acetyltransferase activity IDA
IDA: Inferred from direct assay
10451024 RGD
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
16166080 RGD
involved in photoperiodism IDA
IDA: Inferred from direct assay
12358739 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
16024134 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
16282194 RGD
involved in response to copper ion IDA
IDA: Inferred from direct assay
10451024 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
17014691 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
17014691 RGD
involved in response to insulin IDA
IDA: Inferred from direct assay
18048060 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
18001324 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
16805813 RGD
involved in response to peptide IEP
IEP: Inferred from expression pattern
16166080 RGD
involved in response to prostaglandin E IDA
IDA: Inferred from direct assay
6268470 RGD
involved in response to zinc ion IDA
IDA: Inferred from direct assay
10451024 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serotonin N-acetyltransferase

  • Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase)

  • Seretonin N-acetyltransferase

  • arylakylamine N-acetyltransferase

  • arylalkylamine N-acetyltransferase

  • serotonin acetylase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-157521 AANAT-IN-1 Inhibitor 99.87% Unkown
HY-179397 AANAT-IN-2 Inhibitor / Unkown
HY-RS00025 AANAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aanat NCBI NCBI:15