Gdi1 - GDP dissociation inhibitor 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25183

Summary

Enables Rab GDP-dissociation inhibitor activity and small GTPase binding activity. Involved in negative regulation of axonogenesis; positive regulation of axon extension; and response to calcium ion. Located in axon; myelin sheath; and neuronal cell body. Part of protein-containing complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability; non-syndromic X-linked intellectual disability 41; and psychotic disorder. Orthologous to human GDI1 (GDP dissociation inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Gdi1 Products (1)

mRNA Protein Name
NM_017088.2 NP_058784.2 rab GDP dissociation inhibitor alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Rab GDP-dissociation inhibitor activity IDA
IDA: Inferred from direct assay
12426384 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
12426384 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of axonogenesis IDA
IDA: Inferred from direct assay
21856246 RGD
involved in positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
9620768 RGD
involved in response to calcium ion IDA
IDA: Inferred from direct assay
12426384 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
9620768 RGD
located in myelin sheath IDA
IDA: Inferred from direct assay
17960831 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
9620768 RGD
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
20926670 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12426384 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rab GDP dissociation inhibitor alpha

  • GDI-1

  • guanosine diphosphate dissociation inhibitor 1

  • rab GDI alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05359 GDI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gdi1 NCBI NCBI:2664