Gdi1 - GDP dissociation inhibitor 1 Gene

Rattus norvegicus

Gene ID: 25183 | Gene type: protein coding

About Gdi1

Summary

Enables Rab GDP-dissociation inhibitor activity and small GTPase binding activity. Involved in negative regulation of axonogenesis; positive regulation of axon extension; and response to calcium ion. Located in axon; myelin sheath; and neuronal cell body. Part of protein-containing complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability; non-syndromic X-linked intellectual disability 41; and psychotic disorder. Orthologous to human GDI1 (GDP dissociation inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Gdi1 Products(1)

mRNA	Protein	Name
NM_017088.2	NP_058784.2	rab GDP dissociation inhibitor alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Rab GDP-dissociation inhibitor activity	IDA IDA: Inferred from direct assay	12426384	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	12426384	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of axonogenesis	IDA IDA: Inferred from direct assay	21856246	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	9620768	RGD
involved in response to calcium ion	IDA IDA: Inferred from direct assay	12426384	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	9620768	RGD
located in myelin sheath	IDA IDA: Inferred from direct assay	17960831	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	9620768	RGD
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	20926670	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12426384	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rab GDP dissociation inhibitor alpha

GDI-1	guanosine diphosphate dissociation inhibitor 1
rab GDI alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05359	GDI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gdi1	NCBI	NCBI:2664

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