Gnrh1 - gonadotropin releasing hormone 1 Gene

Rattus norvegicus

Also known as Gnrh; Lhrh; SH-4; Gnrha; Rgnrhg1

Gene ID: 25194 | Gene type: protein coding

About Gnrh1

Summary

Enables gonadotropin hormone-releasing hormone activity. Involved in several processes, including estrous cycle; negative regulation of immature T cell proliferation; and response to Prolactin. Located in several cellular components, including cytoplasmic side of rough endoplasmic reticulum membrane; cytoplasmic vesicle; and perikaryon. Used to study prostatic hypertrophy. Human ortholog(s) of this gene implicated in breast cancer; hypogonadotropic hypogonadism 12 with or without anosmia; and periodontitis. Orthologous to human GNRH1 (gonadotropin releasing hormone 1). [provided by Alliance of Genome Resources, Apr 2022]

Gnrh1 Products(1)

mRNA	Protein	Name
NM_012767.2	NP_036899.1	progonadoliberin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables gonadotropin hormone-releasing hormone activity	IDA IDA: Inferred from direct assay	9256511	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in estrous cycle	IEP IEP: Inferred from expression pattern	9075691	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	17283369	RGD
involved in male sex determination	IMP IMP: Inferred from mutant phenotype	7012206	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12457038	RGD
involved in negative regulation of immature T cell proliferation	IMP IMP: Inferred from mutant phenotype	11092955	RGD
involved in ovulation cycle	IEP IEP: Inferred from expression pattern	16672174	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	9075691	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	3282935	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	7760850	RGD
involved in response to potassium ion	IEP IEP: Inferred from expression pattern	3282935	RGD
involved in response to prolactin	IEP IEP: Inferred from expression pattern	7760850	RGD
involved in response to prostaglandin E	IEP IEP: Inferred from expression pattern	3282935	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	9771467	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi-associated vesicle	IDA IDA: Inferred from direct assay	2183089	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	3044520	RGD
located in cytoplasmic side of rough endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	2183089	RGD
located in dendrite	IDA IDA: Inferred from direct assay	6183141	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	17283369	RGD
located in neurosecretory vesicle	IDA IDA: Inferred from direct assay	6183141	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	11842221	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

progonadoliberin-1

Putative protein SH	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
luteinizing hormone-releasing hormone	progonadoliberin I

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05576	GNRH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gnrh1	NCBI	NCBI:2796

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