Bckdha - branched chain keto acid dehydrogenase E1 subunit alpha Gene

Also Known as E1a; BCKDA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25244

Summary

Predicted to enable 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity. Involved in response to cAMP; response to glucocorticoid; and response to nutrient. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial alpha-ketoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human BCKDHA (branched chain keto acid dehydrogenase E1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Bckdha Products (1)

mRNA Protein Name
NM_012782.1 NP_036914.1 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
3619032 RGD
Biological Process GO Annotation Evidence References Source
involved in response to cAMP IEP
IEP: Inferred from expression pattern
8034710 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
8034710 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
8109974 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

  • BCKDE1A

  • BCKDH E1-alpha

  • branched chain alpha-ketoacid dehydrogenase subunit E1 alpha

  • branched chain keto acid dehydrogenase subunit E1, alpha polypeptide

  • branched chain ketoacid dehydrogenase E1, alpha polypeptide

  • branched-chain alpha-keto acid dehydr

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01409 BCKDHA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bckdha NCBI NCBI:593