Ghrhr - growth hormone releasing hormone receptor Gene

Also Known as GHRHREC

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25321

Summary

Enables growth hormone-releasing hormone receptor activity. Involved in several processes, including activation of Adenylate Cyclase activity; cAMP-mediated signaling; and positive regulation of circadian sleep/wake cycle, non-REM sleep. Located in cell surface and sarcolemma. Used to study isolated growth hormone deficiency. Biomarker of sleep disorder. Human ortholog(s) of this gene implicated in isolated growth hormone deficiency. Orthologous to human GHRHR (growth hormone releasing hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ghrhr Products (3)

mRNA Protein Name
NM_001398554.1 NP_001385483.1 growth hormone-releasing hormone receptor isoform 2
NM_001398565.1 NP_001385494.1 growth hormone-releasing hormone receptor isoform 3 precursor
NM_012850.3 NP_036982.1 growth hormone-releasing hormone receptor isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables growth hormone-releasing hormone receptor activity IDA
IDA: Inferred from direct assay
11814616 RGD
Biological Process GO Annotation Evidence References Source
involved in activation of adenylate cyclase activity IDA
IDA: Inferred from direct assay
9845677 RGD
involved in cAMP/PKA signal transduction IDA
IDA: Inferred from direct assay
10465288 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
18285528 RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep IMP
IMP: Inferred from mutant phenotype
20237285 RGD
involved in positive regulation of growth hormone secretion IMP
IMP: Inferred from mutant phenotype
23825127 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
10465288 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
19293247 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth hormone-releasing hormone receptor

  • GHRH receptor

  • GRF receptor

  • GRFR

  • Growth hormone - releasing receptor

  • growth hormone-releasing factor receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0089A Human growth hormone-releasing factor TFA Activator 99.49% Unkown
HY-P0089 Human growth hormone-releasing factor Activator 98.72% Unkown
HY-P3594 [His1,Nle27] GHRF (1-32), amide, human Activator / Unkown
HY-RS05414 GHRHR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19006 Ghrhr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25495 Ghrhr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ghrhr NCBI NCBI:2692