LCLAT1 - lysocardiolipin acyltransferase 1 Gene

Also Known as LYCAT; AGPAT8; ALCAT1; LPLAT6; 1AGPAT8; UNQ1849; HSRG1849

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 253558

About LCLAT1

Cytogenetic location: 2p23.1 Genomic coordinates (GRCh38): 2:30,447,246-30,644,225 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 4.7), duodenum (RPKM 3.7) and 25 other tissues.

Summary

Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

LCLAT1 Products (4)

mRNA Protein Name
NM_001002257.3 NP_001002257.1 lysocardiolipin acyltransferase 1 isoform 2
NM_001304445.2 NP_001291374.1 lysocardiolipin acyltransferase 1 isoform 2
NM_001304446.2 NP_001291375.1 lysocardiolipin acyltransferase 1 isoform 3
NM_182551.5 NP_872357.2 lysocardiolipin acyltransferase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
IDA: Inferred from direct assay
16620771 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16620771 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCLAT1 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (104 - 261)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
Protein Preferred Names Protein Names

lysocardiolipin acyltransferase 1

  • 1-AGP acyltransferase 8

LCLAT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LCLAT1 Q6UWP7 GOPC Homo sapiens Q9HD26
Validated Y2H
25416956
Intra
LCLAT1 Q6UWP7 GOPC Homo sapiens Q9HD26
Y2H Array
25416956
Intra
LCLAT1 Q6UWP7 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
Intra
LCLAT1 Q6UWP7 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
LCLAT1 Q6UWP7 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
LCLAT1 Q6UWP7 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Barth Syndrome

  • 3-Methylglutaconic Aciduria Type 2

  • BTHS

  • Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria

  • Mga Type Ii

  • Mga2

  • Mgca2

  • Mga Type 2

  • 3-Methylglutaconic Aciduria Type Ii

  • 3-Methylglutaconic Aciduria, Type Ii

  • Mga, Type Ii

  • 3-Methylglutaconicaciduria Type 2

  • 3-Methylglutaconicaciduria Type Ii

  • Taz Defect

  • 3 Methylglutaconic Aciduria, Type Ii

  • Dnajc19 Defect

  • Cardioskeletal Myopathy-Neutropenia Syndrome

  • X-Linked Cardioskeletal Myopathy And Neutropenia

  • 3-Alpha-Methylglutaconic Aciduria Type 2

  • Agm2

  • Cardioskeletal Myopathy-Neutropenia

  • Invm

  • Left Ventricular Non-Compaction Isolated X-Linked

  • Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked

  • Agammaglobulinemia 2, Autosomal Recessive
Mitochondrial Trifunctional Protein Deficiency

  • Tfp Deficiency

  • MTPD

  • Trifunctional Protein Deficiency

  • Trifunctional Protein Deficiency With Myopathy And Neuropathy

  • Tfpd

  • Familial Hypertrophic Cardiomyopathy

  • Cardiomyopathy Familial Hypertrophic

  • Familial Hcm

  • Heritable Hypertrophic Cardiomyopathy

  • Mtp Deficiency

  • Tpa Deficiency

  • Trifunctional Protein Deficiency, Type 2

  • Abetalipoproteinemia
Congenital Generalized Lipodystrophy

  • Berardinelli-Seip Congenital Lipodystrophy

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome

  • Bscl

  • Generalized Lipodystrophy

  • Lipodystrophy, Congenital Generalized

  • Seip Syndrome

  • Total Lipodystrophy

  • Cgl

  • Lipoatrophic Diabetes

  • Lipodystrophy, Generalized, Congenital

  • Familial Generalized Lipodystrophy

  • Congenital Generalized Lipodystrophy Type 2

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07551 LCLAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LCLAT1 VGNC VGNC:107213
Rattus norvegicus LCLAT1 RGD RGD:1565906
Felis catus LCLAT1 VGNC VGNC:81111
Bos taurus LCLAT1 VGNC VGNC:30811
Canis familiaris LCLAT1 VGNC VGNC:42608
Mus musculus LCLAT1 MGD MGI:2684937
Others LCLAT1 NCBI