Asic2 - acid sensing ion channel subunit 2 Gene

Also Known as MDEG; Accn1; BNC1k; BNaC1; MDEG1; MDEG2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25364

Summary

Enables voltage-gated Sodium Channel activity. Involved in several processes, including cellular response to acidic pH; positive regulation of cation channel activity; and sodium ion transport. Predicted to be located in dendritic spine and neuronal cell body. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human ASIC2 (acid sensing ion channel subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Asic2 Products (2)

mRNA Protein Name
NM_001034014.1 NP_001029186.1 acid-sensing ion channel 2 isoform MDEG1
NM_012892.2 NP_037024.2 acid-sensing ion channel 2 isoform MDEG2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
14976185 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17167420 RGD
enables voltage-gated sodium channel activity IDA
IDA: Inferred from direct assay
9368048 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to acidic pH IDA
IDA: Inferred from direct assay
12736332 RGD
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
12736332 RGD
involved in positive regulation of cation channel activity IDA
IDA: Inferred from direct assay
12736332 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
9368048 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acid-sensing ion channel 2

  • BNC1

  • acid-sensing (proton-gated) ion channel 2

  • acid-sensing proton-gated ion channel 2 short variant MDEG2

  • amiloride-sensitive brain sodium channel 2

  • amiloride-sensitive cation channel 1, neuronal

  • brain sodium channel 1

  • degenerin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101005 N-Methylhistamine dihydrochloride 99.99% Unkown
HY-P5174 MitTx Activator 98.0% Unkown
HY-P1441A Mambalgin 1 TFA Inhibitor 95.72% Unkown
HY-P5172 MitTx-alpha Agonist / Unkown
HY-RS01090 ASIC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asic2 NCBI NCBI:40