Apobec1 - apolipoprotein B mRNA editing enzyme catalytic subunit 1 Gene

Also Known as REPR; apobec-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25383

Summary

Enables several functions, including enzyme activator activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; and ribonucleoprotein complex binding activity. Involved in several processes, including cellular response to Insulin stimulus; nucleic acid metabolic process; and positive regulation of mRNA modification. Located in cytoplasm and nucleus. Used to study familial hyperlipidemia and liver benign neoplasm. Biomarker of colon Cancer and obesity. Orthologous to human APOBEC1 (Apolipoprotein B mRNA editing enzyme catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Apobec1 Products (1)

mRNA Protein Name
NM_012907.2 NP_037039.1 C->U-editing enzyme APOBEC-1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cytidine deaminase activity IDA
IDA: Inferred from direct assay
8511591 RGD
enables cytosine deaminase activity IDA
IDA: Inferred from direct assay
12697753 RGD
enables enzyme activator activity IDA
IDA: Inferred from direct assay
9792439 RGD
enables mRNA binding IDA
IDA: Inferred from direct assay
9792439 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10781591 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
9792439 RGD
enables ribonucleoprotein complex binding IPI
IPI: Inferred from physical interaction
9792439 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA cytosine deamination IDA
IDA: Inferred from direct assay
12697753 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
9667237 RGD
involved in cytidine to uridine editing IDA
IDA: Inferred from direct assay
12020819 RGD
involved in defense response to virus IDA
IDA: Inferred from direct assay
15296758 RGD
involved in mRNA modification IDA
IDA: Inferred from direct assay
8511591 RGD
involved in positive regulation of mRNA modification IDA
IDA: Inferred from direct assay
9792439 RGD
involved in response to calcium ion IDA
IDA: Inferred from direct assay
11027667 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
9826530 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
11116209 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
10498758 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C->U-editing enzyme APOBEC-1

  • Apolipoprotein B editing protein

  • apolipoprotein B editing complex 1

  • apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

  • apolipoprotein B mRNA-editing enzyme 1

  • mRNA(cytosine(6666)) deaminase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00834 APOBEC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apobec1 NCBI NCBI:339