Apobec1 - apolipoprotein B mRNA editing enzyme catalytic subunit 1 Gene

Rattus norvegicus

Also known as REPR; apobec-1

Gene ID: 25383 | Gene type: protein coding

About Apobec1

Summary

Enables several functions, including enzyme activator activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; and ribonucleoprotein complex binding activity. Involved in several processes, including cellular response to Insulin stimulus; nucleic acid metabolic process; and positive regulation of mRNA modification. Located in cytoplasm and nucleus. Used to study familial hyperlipidemia and liver benign neoplasm. Biomarker of colon Cancer and obesity. Orthologous to human APOBEC1 (Apolipoprotein B mRNA editing enzyme catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Apobec1 Products(1)

mRNA	Protein	Name
NM_012907.2	NP_037039.1	C->U-editing enzyme APOBEC-1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytidine deaminase activity	IDA IDA: Inferred from direct assay	8511591	RGD
enables cytosine deaminase activity	IDA IDA: Inferred from direct assay	12697753	RGD
enables enzyme activator activity	IDA IDA: Inferred from direct assay	9792439	RGD
enables mRNA binding	IDA IDA: Inferred from direct assay	9792439	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10781591	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	9792439	RGD
enables ribonucleoprotein complex binding	IPI IPI: Inferred from physical interaction	9792439	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA cytosine deamination	IDA IDA: Inferred from direct assay	12697753	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	9667237	RGD
involved in cytidine to uridine editing	IDA IDA: Inferred from direct assay	12020819	RGD
involved in defense response to virus	IDA IDA: Inferred from direct assay	15296758	RGD
involved in mRNA modification	IDA IDA: Inferred from direct assay	8511591	RGD
involved in positive regulation of mRNA modification	IDA IDA: Inferred from direct assay	9792439	RGD
involved in response to calcium ion	IDA IDA: Inferred from direct assay	11027667	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	9826530	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	11116209	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	10498758	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

C->U-editing enzyme APOBEC-1

Apolipoprotein B editing protein	apolipoprotein B editing complex 1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	apolipoprotein B mRNA-editing enzyme 1
mRNA(cytosine(6666)) deaminase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00834	APOBEC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apobec1	NCBI	NCBI:339

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