Gabrb1 - gamma-aminobutyric acid type A receptor subunit beta1 Gene

Rattus norvegicus

Also known as GARB1

Gene ID: 25450 | Gene type: protein coding

About Gabrb1

Summary

Enables GABA Receptor binding activity; GABA-A receptor activity; and ion channel activity. Involved in several processes, including cellular response to histamine; central nervous system neuron development; and response to progesterone. Located in several cellular components, including cytoplasm; dendrite; and nuclear envelope. Is integral component of plasma membrane. Part of GABA-A receptor complex. Is active in GABA-ergic synapse. Biomarker of hepatic encephalopathy. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 45. Orthologous to human GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1). [provided by Alliance of Genome Resources, Apr 2022]

Gabrb1 Products(1)

mRNA	Protein	Name
NM_012956.2	NP_037088.1	gamma-aminobutyric acid receptor subunit beta-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GABA receptor binding	IPI IPI: Inferred from physical interaction	17959749	RGD
enables GABA-A receptor activity	IDA IDA: Inferred from direct assay	2548852	RGD
enables GABA-A receptor activity	IMP IMP: Inferred from mutant phenotype	2540033	RGD
enables ligand-gated monoatomic ion channel activity	IMP IMP: Inferred from mutant phenotype	2540033	RGD
enables monoatomic anion channel activity	IDA IDA: Inferred from direct assay	2479580	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP EXP: Inferred from Experiment	16469775	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	16469775	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to histamine	IDA IDA: Inferred from direct assay	18281286	RGD
involved in central nervous system neuron development	IEP IEP: Inferred from expression pattern	15158077	RGD
involved in monoatomic ion transport	IMP IMP: Inferred from mutant phenotype	2540033	RGD
involved in ovulation cycle	IEP IEP: Inferred from expression pattern	16226387	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	15834956	RGD
involved in response to toxic substance	IDA IDA: Inferred from direct assay	2479580	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of GABA-A receptor complex	IMP IMP: Inferred from mutant phenotype	2540033	RGD
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	16469775	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	15174078	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16226387	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	20511229	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	2540033	RGD
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	15174078	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	15174078	RGD
part of receptor complex	IDA IDA: Inferred from direct assay	17959749	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor subunit beta-1

GABA(A) receptor subunit beta-1	Gamma-aminobutyric acid receptor beta 1
gamma-aminobutyric acid (GABA) A receptor, beta 1	gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1
gamma-aminobutyric acid type A receptor beta 1 subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05215	GABRB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gabrb1	NCBI	NCBI:2560

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