Kcna2 - potassium voltage-gated channel subfamily A member 2 Gene

Also Known as BK2; NGK1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25468

Summary

Enables delayed rectifier Potassium Channel activity; Kinesin binding activity; and outward rectifier Potassium Channel activity. Involved in neuronal action potential; potassium ion export across plasma membrane; and sensory perception of pain. Located in juxtaparanode region of axon and lamellipodium. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Is active in calyx of Held. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32. Orthologous to human KCNA2 (potassium voltage-gated channel subfamily A member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcna2 Products (1)

mRNA	Protein	Name
NM_012970.4	NP_037102.1	potassium voltage-gated channel subfamily A member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables delayed rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	19713757	RGD
enables kinesin binding	IPI IPI: Inferred from physical interaction	17241275	RGD
enables outward rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	12127166	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7477295	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	12777451	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	EXP EXP: Inferred from Experiment	12777451	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	12777451	RGD
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	1715584	RGD
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	2555158	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in corpus callosum development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in neuronal action potential	IMP IMP: Inferred from mutant phenotype	12177193	RGD
involved in optic nerve development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in potassium ion export across plasma membrane	IMP IMP: Inferred from mutant phenotype	12127166	RGD
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	2555158	RGD
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	24472174	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in calyx of Held	EXP EXP: Inferred from Experiment	12777451	RGD
is active in calyx of Held	IDA IDA: Inferred from direct assay	12777451	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	12777451	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12777451	RGD
located in juxtaparanode region of axon	IDA IDA: Inferred from direct assay	10624965	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	12151401	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	2555158	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	14614103	RGD
part of potassium channel complex	IDA IDA: Inferred from direct assay	9334400	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	14614103	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	23705070	RGD
part of voltage-gated potassium channel complex	IMP IMP: Inferred from mutant phenotype	12177193	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
potassium voltage-gated channel subfamily A member 2	Potassium (K+) channel protein alpha 2, voltage dependent Potassium voltage gated channel shaker related subfamily member 2 RAK RBK2 RCK5 potassium channel, voltage gated shaker related subfamily A, member 2 potassium voltage-gated channel, shaker-r

Kcna2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Kcna2	P63142	DLG4	Homo sapiens	P78352	Y2H	7477295
Cross	Kcna2	P63142	DLG4	Homo sapiens	P78352	Far-WB	7477295

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07098	KCNA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcna2	NCBI	NCBI:3737