Otc - ornithine transcarbamylase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25611

Summary

Enables several functions, including identical protein binding activity; ornithine carbamoyltransferase activity; and phosphate ion binding activity. Involved in several processes, including alpha-amino acid metabolic process; response to biotin; and urea cycle. Located in mitochondrial inner membrane. Used to study ornithine carbamoyltransferase deficiency. Biomarker of cholestasis; fatty liver disease; and obesity. Human ortholog(s) of this gene implicated in ornithine carbamoyltransferase deficiency. Orthologous to human OTC (ornithine transcarbamylase). [provided by Alliance of Genome Resources, Apr 2022]

Otc Products (1)

mRNA Protein Name
NM_013078.2 NP_037210.1 ornithine transcarbamylase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amino acid binding IMP
IMP: Inferred from mutant phenotype
2290837 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
2290837 RGD
enables ornithine carbamoyltransferase activity IDA
IDA: Inferred from direct assay
3680220 RGD
enables ornithine carbamoyltransferase activity IMP
IMP: Inferred from mutant phenotype
2290837 RGD
enables phosphate ion binding IMP
IMP: Inferred from mutant phenotype
2290837 RGD
enables phospholipid binding IDA
IDA: Inferred from direct assay
3680220 RGD
Biological Process GO Annotation Evidence References Source
involved in citrulline biosynthetic process IDA
IDA: Inferred from direct assay
9472964 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
8690412 RGD
involved in midgut development IEP
IEP: Inferred from expression pattern
9544996 RGD
involved in monoatomic anion homeostasis IDA
IDA: Inferred from direct assay
4062872 RGD
involved in ornithine metabolic process IDA
IDA: Inferred from direct assay
4062872 RGD
involved in response to biotin IEP
IEP: Inferred from expression pattern
8558326 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
9628242 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
9628242 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
14625847 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
11686784 RGD
involved in urea cycle IDA
IDA: Inferred from direct assay
3680220 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
3680220 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ornithine transcarbamylase, mitochondrial

  • OTCase

  • ornithine carbamoyltransferase, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125947 4-Epioxytetracycline 99.16% Unkown
HY-RS09859 OTC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17937 Otc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24408 Otc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Otc NCBI NCBI:5009