LSM14A - LSM14A mRNA processing body assembly factor Gene

Also Known as RAP55; FAM61A; RAP55A; C19orf13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26065

About LSM14A

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:34,172,504-34,229,288 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 245 orthologues, 1 paralogue and is associated with 62 phenotypes. Ubiquitous expression in thyroid (RPKM 23.9), lymph node (RPKM 21.2) and 25 other tissues.

Summary

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]

LSM14A Products (20)

mRNA	Protein	Name
NM_001114093.3	NP_001107565.1	protein LSM14 homolog A isoform a
NM_001384420.1	NP_001371349.1	protein LSM14 homolog A isoform c
NM_001384421.1	NP_001371350.1	protein LSM14 homolog A isoform d
NM_001384422.1	NP_001371351.1	protein LSM14 homolog A isoform e
NM_001384423.1	NP_001371352.1	protein LSM14 homolog A isoform f
NM_001384424.1	NP_001371353.1	protein LSM14 homolog A isoform g
NM_001384425.1	NP_001371354.1	protein LSM14 homolog A isoform h
NM_001384426.1	NP_001371355.1	protein LSM14 homolog A isoform i
NM_001384427.1	NP_001371356.1	protein LSM14 homolog A isoform j
NM_001384428.1	NP_001371357.1	protein LSM14 homolog A isoform k
NM_001384429.1	NP_001371358.1	protein LSM14 homolog A isoform l
NM_001384430.1	NP_001371359.1	protein LSM14 homolog A isoform m
NM_001384431.1	NP_001371360.1	protein LSM14 homolog A isoform n
NM_001384432.1	NP_001371361.1	protein LSM14 homolog A isoform o
NM_001384433.1	NP_001371362.1	protein LSM14 homolog A isoform o
NM_001384434.1	NP_001371363.1	protein LSM14 homolog A isoform o
NM_001384435.1	NP_001371364.1	protein LSM14 homolog A isoform p
NM_001384436.1	NP_001371365.1	protein LSM14 homolog A isoform q
NM_001384437.1	NP_001371366.1	protein LSM14 homolog A isoform r
NM_015578.4	NP_056393.2	protein LSM14 homolog A isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	29510985	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in P-body assembly	IDA IDA: Inferred from direct assay	16484376	GOA
involved in P-body assembly	IMP IMP: Inferred from mutant phenotype	17074753	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	26339800	GOA
involved in negative regulation of translation	IMP IMP: Inferred from mutant phenotype	29510985	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	16484376	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16484376	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	16484376	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	26339800	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM14A Protein Structure

LSM14

FDF

0
100
200
300
400
463 a.a.

Protein Preferred Names	Protein Names
protein LSM14 homolog A	LSM14 homolog A

Related Diseases

Diseases	Alias
Chromosome 19q13.11 Deletion Syndrome	19q13.11 Microdeletion Syndrome Monosomy 19q13.11 Del(19)(Q13.11)
Spinal Cord Neuroblastoma	Neuroblastoma Of The Spinal Cord
Spinal Cord Primitive Neuroectodermal Neoplasm	Spinal Cord Pnet Spinal Cord Primitive Neuroectodermal Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160222	HSV-60mer sodium		98.11%	Unkown
HY-RS07856	LSM14A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LSM14A	VGNC	VGNC:42841
Macaca mulatta	LSM14A	VGNC	VGNC:103832
Bos taurus	LSM14A	VGNC	VGNC:31053
Mus musculus	LSM14A	MGD	MGI:1914320
Felis catus	LSM14A	VGNC	VGNC:63322
Rattus norvegicus	LSM14A	RGD	RGD:1305695
Others	LSM14A	NCBI