FGF20 - fibroblast growth factor 20 Gene

Also Known as RHDA2; FGF-20

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26281

About FGF20

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:16,992,181-17,002,345 (from NCBI)

This gene has 2 transcripts (splice variants), 265 orthologues, 21 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the Fibroblast Growth Factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]

FGF20 Products (1)

mRNA Protein Name
NM_019851.3 NP_062825.1 fibroblast growth factor 20

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables receptor-receptor interaction IDA
IDA: Inferred from direct assay
24157794 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
16988046 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGF20 Protein Structure

FGF

FGF: Fibroblast growth factor (65 - 191)

  • 0
  • 100
  • 200
  • 211 a.a.
Protein Preferred Names Protein Names

fibroblast growth factor 20

Recombinant FGF20 Proteins

Cat. No. Product Name Accession Purity
HY-P700062AF Animal-Free FGF-20 Protein, Human (His) Q9NP95 (P3-T211) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Renal Hypodysplasia/Aplasia 2

  • RHDA2

  • Hypodysplasia/Aplasia, Renal, Type 2
Renal Agenesis, Bilateral

  • Bilateral Renal Agenesis
Bilateral Renal Aplasia
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Potter'S Syndrome

  • Potter Sequence

  • Potter Syndrome

  • Oligohydramnios Sequence

  • Congenital Absence Of Kidneys Syndrome
Townes-Brocks Syndrome

  • Townes Syndrome

  • Renal-Ear-Anal-Radial Syndrome

  • Anus, Imperforate, With Hand, Foot And Ear Anomalies

  • Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome

  • Rear Syndrome

  • Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs

  • Tbs

  • Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs

  • Imperforate Anus With Hand, Foot And Ear Anomalies

  • Anal-Ear-Renal-Radial Malformation Syndrome

  • Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome

  • Imperforate Anus-Hand And Foot Anomalies Syndrome

  • Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome

  • Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs
Renal Hypodysplasia/Aplasia 1

  • Renal Agenesis

  • Renal Adysplasia

  • Renal Aplasia

  • RHDA1

  • Hereditary Renal Aplasia

  • Hra

  • Hereditary Urogenital Adysplasia

  • Hypodysplasia/Aplasia, Renal, Type 1

  • Congenital Absence Of Kidneys Syndrome

  • Congenital Absence Of Kidney

  • Aplastic Kidney
Cakut

  • Renal Or Urinary Tract Malformation

  • Congenital Anomalies Of Kidney And Urinary Tract

  • Congenital Anomaly Of Kidney And Urinary Tract

  • Congenital Anomalies Of The Kidney And Urinary Tract

  • Kidney And Urinary Tract, Anomalies, Congenital

  • Renal Hypodysplasia, Nonsyndromic, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169348 β-catenin-IN-8 Inhibitor / Unkown
HY-RS04897 FGF20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174701 Human FGF20 mRNA / Unkown
HY-RS19003 Fgf20 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25492 Fgf20 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FGF20 VGNC VGNC:104454
Felis catus FGF20 VGNC VGNC:107333
Mus musculus FGF20 MGD MGI:1891346
Rattus norvegicus FGF20 RGD RGD:71068
Canis familiaris FGF20 VGNC VGNC:51802
Bos taurus FGF20 VGNC VGNC:28976
Others FGF20 NCBI