Ttc26 - tetratricopeptide repeat domain 26 Gene

Mus musculus

Also known as hop; hpy; Ift56; 9330141E21Rik; 9430097H08Rik

Gene ID: 264134 | Gene type: protein coding

About Ttc26

Summary

Enables intraciliary transport particle B binding activity. Involved in cilium organization; protein localization to cilium; and smoothened signaling pathway. Acts upstream of or within manchette assembly. Located in centrosome and ciliary basal body. Part of intraciliary transport particle B. Orthologous to human TTC26 (tetratricopeptide repeat domain 26). [provided by Alliance of Genome Resources, Apr 2022]

Ttc26 Products(1)

mRNA	Protein	Name
NM_153600.2	NP_705828.2	intraflagellar transport protein 56

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables intraciliary transport particle B binding	IDA IDA: Inferred from direct assay	19253336	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25340710	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in axoneme assembly	IMP IMP: Inferred from mutant phenotype	28264835	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	22718903	MGI
involved in intraciliary transport	IMP IMP: Inferred from mutant phenotype	25340710	MGI
acts upstream of or within manchette assembly	IMP IMP: Inferred from mutant phenotype	9674995	MGI
involved in protein localization to cilium	IMP IMP: Inferred from mutant phenotype	28264835	MGI
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	25340710	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	7317942	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	19253336	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	22718903	MGI
located in cilium	IDA IDA: Inferred from direct assay	19253336	MGI
part of intraciliary transport particle B	IDA IDA: Inferred from direct assay	24596149	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	22718903	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

intraflagellar transport protein 56

TPR repeat protein 26	hydrocephalic-polydactyl
protein hop-sterile	tetratricopeptide repeat protein 26

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15204	TTC26 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ttc26	NCBI	NCBI:79989

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