TTC26 - tetratricopeptide repeat domain 26 Gene

Also Known as BRENS; DYF13; IFT56; dyf-13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79989

About TTC26

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:139,133,778-139,191,986 (from NCBI)

This gene has 10 transcripts (splice variants), 226 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 5.7), thyroid (RPKM 2.6) and 23 other tissues.

Summary

Predicted to enable intraciliary transport particle B binding activity. Predicted to be involved in cilium organization; protein localization to cilium; and smoothened signaling pathway. Predicted to act upstream of or within manchette assembly. Predicted to be located in cilium. Predicted to be part of intraciliary transport particle B. Predicted to be active in ciliary basal body and ciliary base. [provided by Alliance of Genome Resources, Apr 2022]

TTC26 Products (9)

mRNA Protein Name
NM_001144920.3 NP_001138392.1 intraflagellar transport protein 56 isoform 2
NM_001144923.3 NP_001138395.1 intraflagellar transport protein 56 isoform 3
NM_001287512.2 NP_001274441.1 intraflagellar transport protein 56 isoform 4
NM_001287513.2 NP_001274442.1 intraflagellar transport protein 56 isoform 5
NM_001318333.2 NP_001305262.1 intraflagellar transport protein 56 isoform 6
NM_001321740.2 NP_001308669.1 intraflagellar transport protein 56 isoform 7
NM_001321741.2 NP_001308670.1 intraflagellar transport protein 56 isoform 8
NM_001321742.2 NP_001308671.1 intraflagellar transport protein 56 isoform 9
NM_024926.4 NP_079202.2 intraflagellar transport protein 56 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
31595528 GOA
Cellular Component GO Annotation Evidence References Source
located in cilium IMP
IMP: Inferred from mutant phenotype
31595528 GOA
part of intraciliary transport particle B IPI
IPI: Inferred from physical interaction
26980730 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTC26 Protein Structure

TPR_11

TPR_11: TPR repeat (64 - 112)

TPR_9

TPR_9: Tetratricopeptide repeat (158 - 225)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 554 a.a.
Protein Preferred Names Protein Names

intraflagellar transport protein 56

  • TPR repeat protein 26

Related Diseases

Diseases Alias
Biliary, Renal, Neurologic, And Skeletal Syndrome

  • BRENS

  • Brens Syndrome
Hydrocephalus

  • Hydrocephalus, Nonsyndromic, Autosomal Recessive

  • Hydrocephalus, X-Linked

  • Hydrocephalus Adverse Event

  • Hydrocephaly Nos
Caroli Disease

  • Caroli Disease Isolated

  • Congenital Polycystic Dilatation Of Intrahepatic Bile Ducts

  • Cystic Dilatation Of The Intrahepatic Biliary Tree

  • Caroli Syndrome

  • Carolis Disease
Bardet-Biedl Syndrome 15

  • BBS15

  • Bardet-Biedl Syndrome, Type 15
Bardet-Biedl Syndrome 3

  • BBS3

  • Bardet-Biedl Syndrome, Type 3
Meckel Syndrome, Type 2

  • MKS2

  • Meckel Syndrome 2

  • Meckel-Gruber Syndrome, Type 2

  • Meckel Syndrome Type 2
Meckel Syndrome, Type 5

  • Meckel Syndrome 5

  • MKS5

  • Meckel-Gruber Syndrome, Type 5
Situs Inversus

  • Situs Inversus Viscerum

  • Laterality Sequence

  • Complete Transposition

  • Siv
Bardet-Biedl Syndrome

  • Bbs

  • Biedl-Bardet Syndrome
Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly

  • Asphyxiating Thoracic Dystrophy 3

  • Saldino-Noonan Syndrome

  • SRTD3

  • Atd3

  • Srps1

  • Srps3

  • Verma-Naumoff Syndrome

  • Srps2b

  • Short Rib-Polydactyly Syndrome, Verma-Naumoff Type

  • Short Rib-Polydactyly Syndrome, Type I

  • Polydactyly With Neonatal Chondrodystrophy, Type I

  • Polydactyly With Neonatal Chondrodystrophy, Type Iii

  • Short Rib-Polydactyly Syndrome, Type Iib

  • Short Rib-Polydactyly Syndrome Type 3

  • Polydactyly With Neonatal Chondrodystrophy Type Iii

  • Short Rib-Polydactyly Syndrome Type Iii

  • Short Rib-Polydactyly Syndrome Type 1

  • Short Rib-Polydactyly Syndrome, Saldino-Noonan Type

  • Majewski Syndrome

  • Short Rib-Polydactyly Syndrome, Type Iii

  • Type I Short Rib Polydactyly Syndrome

  • Srps Type 3

  • Short Rib Polydactyly Syndrome Verma Naumoff Type

  • Verma Naumoff Syndrome

  • Polydactyly With Neonatal Chondrodystrophy Type 1

  • Srps Type 1

  • Short Rib-Polydactyly Syndrome Saldino-Noonan Type

  • Jatd

  • Jeune Asphyxiating Thoracic Dystrophy

  • Jeune Syndrome 3

  • Polydactyly With Neonatal Chondrodystrophy Type I

  • Short Rib-Polydactyly Syndrome Type I

  • Short Rib-Polydactyly Syndrome Type Iib

  • Srps Type Iib

  • Srps Type Iii
Short-Rib Thoracic Dysplasia 12

  • Beemer-Langer Syndrome

  • Type Iv Short Rib Polydactyly Syndrome

  • Short Rib-Polydactyly Syndrome Type 4

  • Short Rib-Polydactyly Syndrome, Beemer Type

  • SRTD12

  • Short Rib-Polydactyly Syndrome, Type Iv

  • Srps4

  • Srps Iv

  • Short Rib Syndrome, Beemer Type

  • Beemer Langer Syndrome

  • Srps Type 4

  • Short Rib Polydactyly Syndrome Beemer-Langer Type

  • Short Rib-Polydactyly Syndrome Beemer Type

  • Short Rib-Polydactyly Syndrome Type Iv

  • Short Rib-Polydactyly Syndrome, Beemer-Langer Type
Polycystic Liver Disease

  • Autosomal Dominant Polycystic Liver Disease

  • Isolated Polycystic Liver Disease

  • Pcld

  • Congenital Cystic Liver Disease

  • Congenital Hepatic Cyst

  • Fibrocystic Liver Disease

  • Isolated Autosomal Dominant Polycystic Liver Disease

  • Adpcld

  • Liver Disease, Polycystic

  • Multiple Cysts Of Liver

  • Pld - [Polycystic Liver Disease]

  • Polycystic Liver Disorder

  • Polycystic Liver

  • Congenital Polycystic Disease Of Liver

  • Congenital Polycystic Liver Disease
Joubert Syndrome 1

  • Joubert Syndrome

  • Jbts

  • Cerebellooculorenal Syndrome 1

  • JBTS1

  • Joubert-Boltshauser Syndrome

  • Cerebelloparenchymal Disorder Iv

  • Cpd4

  • Cors1

  • Joubert Syndrome And Related Disorders

  • Jsrd

  • Familial Aplasia Of The Vermis

  • Joubert Syndrome Related Disorders

  • Js

  • Cerebellar Vermis Agenesis

  • Cerebelloparenchymal Disorder 4

  • Agenesis Of Cerebellar Vermis

  • Cerebello-Oculo-Renal Syndrome

  • Cors

  • Joubert-Bolthauser Syndrome

  • Cpd Iv

  • Classic Joubert Syndrome

  • Joubert Syndrome Type A

  • Pure Joubert Syndrome

  • Cerebello-Oculo-Renal Syndrome 1

  • Joubert Syndrome-1

  • Joubert Syndrome, Type 1

  • Joubert'S Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15204 TTC26 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TTC26 VGNC VGNC:47947
Macaca mulatta TTC26 VGNC VGNC:79341
Mus musculus TTC26 MGD MGI:2444853
Rattus norvegicus TTC26 RGD RGD:1561363
Bos taurus TTC26 VGNC VGNC:36465
Felis catus TTC26 VGNC VGNC:66662
Others TTC26 NCBI