Ern2 - endoplasmic reticulum (ER) to nucleus signalling 2 Gene

Also Known as Ern1; Ire1; Ire1b; mIre1; ire1-beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26918

Summary

Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and unfolded protein binding activity. Involved in several processes, including positive regulation of JUN kinase activity; regulation of transcription, DNA-templated; and response to endoplasmic reticulum stress. Acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Located in endoplasmic reticulum quality control compartment. Part of IRE1-TRAF2-ASK1 complex. Is expressed in central nervous system and retina. Orthologous to human ERN2 (endoplasmic reticulum to nucleus signaling 2). [provided by Alliance of Genome Resources, Apr 2022]

Ern2 Products (2)

mRNA Protein Name
NM_001316689.1 NP_001303618.1 serine/threonine-protein kinase/endoribonuclease IRE2 isoform 2 precursor
NM_012016.3 NP_036146.2 serine/threonine-protein kinase/endoribonuclease IRE2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10650002 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
9755171 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
9755171 MGI
involved in positive regulation of JUN kinase activity IDA
IDA: Inferred from direct assay
10650002 MGI
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9755171 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
10650002 MGI
acts upstream of or within response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
11238559 MGI
Cellular Component GO Annotation Evidence References Source
part of IRE1-TRAF2-ASK1 complex IDA
IDA: Inferred from direct assay
12050113 MGI
located in endoplasmic reticulum quality control compartment IDA
IDA: Inferred from direct assay
17707796 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase/endoribonuclease IRE2

  • endoplasmic reticulum-to-nucleus signaling 2

  • inositol-requiring 1 (Yeast homologue)

  • inositol-requiring 1 beta

  • inositol-requiring protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04510 ERN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ern2 NCBI NCBI:10595