MORC1 - MORC family CW-type zinc finger 1 Gene

Also Known as CT33; MORC; ZCW6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27136

About MORC1

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:108,958,248-109,118,134 (from NCBI)

This gene has 2 transcripts (splice variants), 86 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 9.4).

Summary

This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into Apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]

MORC1 Products (1)

mRNA	Protein	Name
NM_014429.4	NP_055244.3	MORC family CW-type zinc finger protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MORC1 Protein Structure

HATPase_c_3

zf-CW

0
200
400
600
800
984 a.a.

Protein Preferred Names	Protein Names
MORC family CW-type zinc finger protein 1	cancer/testis antigen 33

MORC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MORC1	Q86VD1	MORC2	Homo sapiens	Q9Y6X9	Anti Tag CoIP	33961781
Intra	MORC1	Q86VD1	MORC2	Homo sapiens	Q9Y6X9	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Charcot-Marie-Tooth Disease, Axonal, Type 2z	CMT2Z Charcot-Marie-Tooth Disease Axonal Type 2z Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2z Charcot-Marie-Tooth Neuropathy, Type 2z Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2z Charcot-Marie-Tooth Neuropathy Type 2z Autosomal Dominant Charcot-Marie-Tooth Disease Type 2z Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Morc2 Mutation Charcot-Marie-Tooth Disease 2z Charcot-Marie-Tooth Disease, Type 2z
Charcot-Marie-Tooth Disease, X-Linked Recessive, 3	CMTX3 Charcot-Marie-Tooth Disease X-Linked Recessive 3 Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 3 Cmt3x X-Linked Charcot-Marie-Tooth Disease Type 3 Charcot-Marie-Tooth Neuropathy X-Linked Recessive 3 Charcot-Marie-Tooth Disease, X-Linked Type 3, Recessive
Holoprosencephaly 1	Arhinencephaly HPE1 Cyclopia Holoprosencephaly, Familial Alobar Hpe, Familial Hpec Demyer Sequence Holoprosencephaly-1
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08589	MORC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22647	Morc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29161	Morc1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MORC1	RGD	RGD:1565610
Felis catus	MORC1	VGNC	VGNC:68299
Canis familiaris	MORC1	VGNC	VGNC:43316
Bos taurus	MORC1	VGNC	VGNC:31554
Macaca mulatta	MORC1	VGNC	VGNC:74910
Mus musculus	MORC1	MGD	MGI:1316740
Others	MORC1	NCBI