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GLI4 - GLI family zinc finger 4 Gene

Also Known as HKR4; ZNF928

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2738

About GLI4

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,267,445-143,276,931 (from NCBI)

This gene has 11 transcripts (splice variants), 66 orthologues and 174 paralogues. Ubiquitous expression in fat (RPKM 5.3), spleen (RPKM 4.2) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

GLI4 Products (1)

mRNA	Protein	Name
NM_138465.4	NP_612474.1	zinc finger protein GLI4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLI4 Protein Structure

zf-H2C2_2

0
100
200
300
376 a.a.

Protein Preferred Names	Protein Names
zinc finger protein GLI4	GLI-Kruppel family member GLI4 (oncogene HKR4)

Related Diseases

Diseases	Alias
Parameningeal Embryonal Rhabdomyosarcoma
Heart Fibrosarcoma	Cardiac Fibrosarcoma Fibrosarcoma Of The Heart
Joubert Syndrome 32	JBTS32
Pleomorphic Rhabdomyosarcoma	Adult Pleomorphic Rhabdomyosarcoma Anaplastic Rhabdomyosarcoma Pleomorphic Rhabdomyosarcoma, Adult Type
46,Xy Sex Reversal 7	SRXY7 46,Xy Sex Reversal, Partial Or Complete, Dhh-Related 46,Xy Gonadal Dysgenesis, Partial Or Complete, Dhh-Related Gdxym Gonadal Dysgenesis, Xy, Male-Limited 46xy Sex Reversal 7 Gonadal Dysgenesis, Xy, Male Limited Complete Pure Gonadal Dysgenesis 46,Xy Type Male-Limited Gonadal Dysgenesis 46,Xy 46,Xy Gonadal Dysgenesis, Complete Or Partial, Dhh-Related
Holoprosencephaly 9	Pituitary Anomalies With Holoprosencephaly-Like Features HPE9 Holoprosencephaly With Microphthalmia And First Branchial Arch Anomalies Holoprosencephaly-9 Holoprosencephaly, Type 9
Holoprosencephaly 7	HPE7 Holoprosencephaly-7 Holoprosencephaly, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05477	GLI4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GLI4	RGD	RGD:1560906
Canis familiaris	GLI4	VGNC	VGNC:41259
Others	GLI4	NCBI