Dusp13 - dual specificity phosphatase 13 Gene

Also Known as MDSP; TMDP; Gm1203; DUSP13A; DUSP13B; TS-DSP6; LMW-DSP6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27389

Summary

Members of the protein-tyrosine Phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In humans, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]

Dusp13 Products (6)

mRNA Protein Name
NM_001007268.1 NP_001007269.1 dual specificity protein phosphatase 13 isoform 1
NM_001374075.1 NP_001361004.1 dual specificity protein phosphatase 13 isoform 3
NM_001374077.1 NP_001361006.1 dual specificity protein phosphatase 13 isoform 4
NM_001374078.1 NP_001361007.1 dual specificity protein phosphatase 13 isoform 4
NM_001374079.1 NP_001361008.1 dual specificity protein phosphatase 13 isoform 4
NM_013849.3 NP_038877.2 dual specificity protein phosphatase 13 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein tyrosine/serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
11432789 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity protein phosphatase 13

  • Dsp13-like protein

  • dual-specificity tyrosine phosphatase TS-DSP6

  • muscle-restricted DSP

  • testis and skeletal muscle-specific dual specificity phosphatase

  • testis- and skeletal muscle-specific DSP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04054 DUSP13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dusp13 NCBI NCBI:51207