GLRA2 - glycine receptor alpha 2 Gene

Homo sapiens

Also known as GLR; MRXSP

Gene ID: 2742 | Gene type: protein coding

About GLRA2

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:14,448,779-14,731,812 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues, 45 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 1.9) and colon (RPKM 0.8).

Summary

The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

GLRA2 Products(4)

mRNA	Protein	Name
NM_001118885.2	NP_001112357.1	glycine receptor subunit alpha-2 isoform A precursor
NM_001118886.2	NP_001112358.1	glycine receptor subunit alpha-2 isoform B precursor
NM_001171942.2	NP_001165413.1	glycine receptor subunit alpha-2 isoform C
NM_002063.4	NP_002054.1	glycine receptor subunit alpha-2 isoform A precursor

GLRA2 Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
452 a.a.

Protein Preferred Names

Protein Names

glycine receptor subunit alpha-2

glycine receptor alpha 2 subunit

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type

MRXSP

Intellectual Developmental Disorder, X-Linked Syndromic, Pilorge Type

Alternating Exotropia

Exotropia

Hyperekplexia

Hereditary Hyperekplexia	Kok Disease
Congenital Stiff Man Syndrome	Familial Startle Disease
Sthe	Stiff-Baby Syndrome
Hereditary Hyperexplexia	Startle Disease
Exaggerated Startle Reaction	Hyperexplexia Hereditary
Startle Disease, Familial	Startle Reaction, Exaggerated
Stiff-Man Syndrome, Congenital	Stiff-Person Syndrome, Congenital
Congenital Stiff-Man Syndrome	Congenital Stiff-Person Syndrome
Familial Hyperekplexia	Startle Syndrome
Stiff Baby Syndrome	Hyperekplexia, Hereditary
Stiff-Person Syndrome

Expressive Language Disorder

Developmental Expressive Language Disorder

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Glycine Encephalopathy

Non-Ketotic Hyperglycinemia	Nonketotic Hyperglycinemia
NKH	GCE
Hyperglycinemia, Nonketotic	Hyperglycinemia Nonketotic
Infantile Glycine Encephalopathy	Encephalopathy, Glycine
Glycine Synthase Deficiency	Nka
Neonatal Glycine Encephalopathy	Classic Glycine Encephalopathy
Neonatal Nkh	Neonatal Non-Ketotic Hyperglycinemia
Infantile Nkh	Infantile Non-Ketotic Hyperglycinemia
Non-Ketotic Hyperglycinaemia	Glycine Cleavage Deficiency
Nonketotic Hyperglycinaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05493	GLRA2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GLRA2	MGD	MGI:95748
Bos taurus	GLRA2	VGNC	VGNC:29413
Felis catus	GLRA2	VGNC	VGNC:62589
Canis familiaris	GLRA2	VGNC	VGNC:41269
Macaca mulatta	GLRA2	VGNC	VGNC:73075
Rattus norvegicus	GLRA2	RGD	RGD:2705

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