GLUD2 - glutamate dehydrogenase 2 Gene

Also Known as GDH2; GLUDP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2747

About GLUD2

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:121,047,610-121,050,094 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 285 orthologues, 1 paralogue and is associated with 1 phenotype.

Summary

The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]

GLUD2 Products (1)

mRNA Protein Name
NM_012084.4 NP_036216.2 glutamate dehydrogenase 2, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP binding IDA
IDA: Inferred from direct assay
12742085 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
11032875 GOA
enables L-leucine binding IDA
IDA: Inferred from direct assay
12742085 GOA
enables glutamate dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
8207021 GOA
enables glutamate dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
11032875 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in glutamate biosynthetic process IDA
IDA: Inferred from direct assay
11032875 GOA
involved in glutamate catabolic process IDA
IDA: Inferred from direct assay
11032875 GOA
involved in glutamate metabolic process IDA
IDA: Inferred from direct assay
8207021 GOA
Cellular Component GO Annotation Evidence References Source
NOT located in cytosol IDA
IDA: Inferred from direct assay
18688271 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
18688271 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLUD2 Protein Structure

ELFV_dehydrog_N

ELFV_dehydrog_N: Glu/Leu/Phe/Val dehydrogenase, dimerisation domain (113 - 241)

ELFV_dehydrog

ELFV_dehydrog: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase (263 - 455)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 558 a.a.
Protein Preferred Names Protein Names

glutamate dehydrogenase 2, mitochondrial

  • GDH 2

GLUD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GLUD2 P49448 GLUD1 Homo sapiens P00367
Anti Tag CoIP
33961781
Intra
GLUD2 P49448 GLUD1 Homo sapiens P00367
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Hereditary Late-Onset Parkinson Disease

  • Autosomal Dominant Late-Onset Parkinson Disease

  • Lopd

  • Hereditary Late Onset Parkinson Disease
Depersonalization Disorder

  • Neurotic Derealization

  • Depersonalization

  • Depersonalization/Derealization Disorder

  • Depersonalisation-Derealization Syndrome

  • Depersonalisation Disorder

  • Depersonalisation Neurosis

  • Depersonalisation Syndrome

  • Feeling Of Unreality

  • Feels Own Self Is Unreal

  • Neurotic State With Depersonalisation

  • Neurotic State With Depersonalization Episode
Hyperinsulinemic Hypoglycemia, Familial, 6

  • Hyperinsulinism-Hyperammonemia Syndrome

  • HHF6

  • Familial Hyperinsulinemic Hypoglycemia 6

  • Hi/Ha Syndrome

  • Ha/Hi Syndrome

  • Hyperinsulinemic Hypoglycemia Familial 6

  • Hyperinsulinism Hyperammonemia Syndrome

  • Hhs
Spastic Paraplegia 34, X-Linked

  • SPG34

  • Hereditary Spastic Paraplegia 34

  • X-Linked Spastic Paraplegia Type 34

  • X-Linked Spastic Paraplegia 34
Glioblastoma Mesenchymal Subtype
Hypoglycemic Coma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05508 GLUD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05796 GRID2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GLUD2 MGD MGI:95753