AANAT - aralkylamine N-acetyltransferase Gene
Species: Bos taurus
Gene Type: protein coding
Gene ID: 281583
Summary
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. [provided by RefSeq, Feb 2014]
AANAT Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_177509.2 | NP_803475.1 | serotonin N-acetyltransferase |
| NM_177509.2 | NP_803475.1 | serotonin N-acetyltransferase |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
serotonin N-acetyltransferase |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(3)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-157521 | AANAT-IN-1 | Inhibitor | 99.87% | Unkown |
| HY-179397 | AANAT-IN-2 | Inhibitor | / | Unkown |
| HY-RS00025 | AANAT Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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