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TTLL6 - tubulin tyrosine ligase like 6 Gene

Also Known as TTL.6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 284076

About TTLL6

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,762,234-48,817,229 (from NCBI)

This gene has 9 transcripts (splice variants), 120 orthologues and 12 paralogues. Biased expression in testis (RPKM 10.4), colon (RPKM 1.9) and 5 other tissues.

Summary

Predicted to enable tubulin binding activity and tubulin-glutamic acid Ligase activity. Predicted to be involved in microtubule Cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within microtubule bundle formation; microtubule severing; and positive regulation of cilium movement. Located in ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]

TTLL6 Products (3)

mRNA	Protein	Name
NM_001130918.3	NP_001124390.1	tubulin polyglutamylase TTLL6 isoform 1
NM_001366314.2	NP_001353243.1	tubulin polyglutamylase TTLL6 isoform 3
NM_173623.4	NP_775894.2	tubulin polyglutamylase TTLL6 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22246503	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	22246503	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTLL6 Protein Structure

TTL

0
200
400
600
800
891 a.a.

Protein Preferred Names	Protein Names
tubulin polyglutamylase TTLL6	protein polyglutamylase TTLL6

Related Diseases

Diseases	Alias
Joubert Syndrome 33	JBTS33 Joubert Syndrome, Type 33
Joubert Syndrome 15	JBTS15 Joubert Syndrome, Type 15
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15233	TTLL6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TTLL6	VGNC	VGNC:36494
Rattus norvegicus	TTLL6	RGD	RGD:1311922
Canis familiaris	TTLL6	VGNC	VGNC:47977
Felis catus	TTLL6	VGNC	VGNC:66688
Macaca mulatta	TTLL6	VGNC	VGNC:79632
Mus musculus	TTLL6	MGD	MGI:2683461