GPS1 - G protein pathway suppressor 1 Gene

Homo sapiens

Also known as CSN1; SGN1; COPS1

Gene ID: 2873 | Gene type: protein coding

About GPS1

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,050,932-82,057,470 (from NCBI)

This gene has 28 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 28.1), testis (RPKM 27.1) and 25 other tissues.

Summary

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]

GPS1 Products(28)

mRNA	Protein	Name
NM_001321089.3	NP_001308018.1	COP9 signalosome complex subunit 1 isoform 3
NM_001321090.3	NP_001308019.1	COP9 signalosome complex subunit 1 isoform 4
NM_001321091.3	NP_001308020.1	COP9 signalosome complex subunit 1 isoform 5
NM_001321092.3	NP_001308021.1	COP9 signalosome complex subunit 1 isoform 6
NM_001321093.3	NP_001308022.1	COP9 signalosome complex subunit 1 isoform 7
NM_001330539.3	NP_001317468.1	COP9 signalosome complex subunit 1 isoform 8
NM_001330541.3	NP_001317470.1	COP9 signalosome complex subunit 1 isoform 9
NM_001394759.1	NP_001381688.1	COP9 signalosome complex subunit 1 isoform 10
NM_001394760.1	NP_001381689.1	COP9 signalosome complex subunit 1 isoform 11
NM_001394761.1	NP_001381690.1	COP9 signalosome complex subunit 1 isoform 12
NM_001394762.1	NP_001381691.1	COP9 signalosome complex subunit 1 isoform 13
NM_001394763.1	NP_001381692.1	COP9 signalosome complex subunit 1 isoform 13
NM_001394764.1	NP_001381693.1	COP9 signalosome complex subunit 1 isoform 14
NM_001394765.1	NP_001381694.1	COP9 signalosome complex subunit 1 isoform 15
NM_001394766.1	NP_001381695.1	COP9 signalosome complex subunit 1 isoform 15
NM_001394767.1	NP_001381696.1	COP9 signalosome complex subunit 1 isoform 15
NM_001394768.1	NP_001381697.1	COP9 signalosome complex subunit 1 isoform 16
NM_001394769.1	NP_001381698.1	COP9 signalosome complex subunit 1 isoform 7
NM_001394770.1	NP_001381699.1	COP9 signalosome complex subunit 1 isoform 7
NM_001394771.1	NP_001381700.1	COP9 signalosome complex subunit 1 isoform 7
NM_001394772.1	NP_001381701.1	COP9 signalosome complex subunit 1 isoform 17
NM_001394773.1	NP_001381702.1	COP9 signalosome complex subunit 1 isoform 17
NM_001394774.1	NP_001381703.1	COP9 signalosome complex subunit 1 isoform 18
NM_001394775.1	NP_001381704.1	COP9 signalosome complex subunit 1 isoform 19
NM_001394776.1	NP_001381705.1	COP9 signalosome complex subunit 1 isoform 20
NM_001394777.1	NP_001381706.1	COP9 signalosome complex subunit 1 isoform 21
NM_004127.7	NP_004118.3	COP9 signalosome complex subunit 1 isoform 2
NM_212492.4	NP_997657.1	COP9 signalosome complex subunit 1 isoform 1

GPS1 Protein Structure

RPN7

PCI

0
100
200
300
400
491 a.a.

Protein Preferred Names

Protein Names

COP9 signalosome complex subunit 1

JAB1-containing signalosome subunit 1

Related Diseases

Diseases

Alias

Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V	Xp5
Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype	Xpe
Xp, Group E	Xeroderma Pigmentosum, Type 5
Xeroderma Pigmentosum Complementation Group E	XP-E
Xp Group E

Corneal Dystrophy, Avellino Type

Avellino Corneal Dystrophy	CDA
Combined Granular-Lattice Corneal Dystrophy	Cgd2
Granular Corneal Dystrophy Type 2	Acd
Granular Corneal Dystrophy 2	Corneal Dystrophy Avellino Type
Granular Corneal Dystrophy Type Ii	Granular Corneal Dystrophy, Type Ii
Combined Granular-Lattice Corneal Dystrophies	Granular And Lattice Corneal Dystrophies
Granular-Lattice Corneal Dystrophy	Gcd2
Gcdii	Granular-Lattice Corneal Dystrophy

Granular Corneal Dystrophy

Granular Dystrophy Corneal	Corneal Dystrophies, Hereditary
Hereditary Corneal Dystrophy	Corneal Dystrophy Nos
Familial Hereditary Corneal Degeneration	Hereditary Corneal Opacity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05757	GPS1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GPS1	RGD	RGD:621532
Macaca mulatta	GPS1	VGNC	VGNC:73149
Mus musculus	GPS1	MGD	MGI:2384801
Canis familiaris	GPS1	VGNC	VGNC:41455
Felis catus	GPS1	VGNC	VGNC:67450
Bos taurus	GPS1	VGNC	VGNC:29612
Others	GPS1	NCBI