GPS1 - G protein pathway suppressor 1 Gene

Also Known as CSN1; SGN1; COPS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2873

About GPS1

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,050,932-82,057,470 (from NCBI)

This gene has 28 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 28.1), testis (RPKM 27.1) and 25 other tissues.

Summary

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]

GPS1 Products (28)

mRNA Protein Name
NM_001321089.3 NP_001308018.1 COP9 signalosome complex subunit 1 isoform 3
NM_001321090.3 NP_001308019.1 COP9 signalosome complex subunit 1 isoform 4
NM_001321091.3 NP_001308020.1 COP9 signalosome complex subunit 1 isoform 5
NM_001321092.3 NP_001308021.1 COP9 signalosome complex subunit 1 isoform 6
NM_001321093.3 NP_001308022.1 COP9 signalosome complex subunit 1 isoform 7
NM_001330539.3 NP_001317468.1 COP9 signalosome complex subunit 1 isoform 8
NM_001330541.3 NP_001317470.1 COP9 signalosome complex subunit 1 isoform 9
NM_001394759.1 NP_001381688.1 COP9 signalosome complex subunit 1 isoform 10
NM_001394760.1 NP_001381689.1 COP9 signalosome complex subunit 1 isoform 11
NM_001394761.1 NP_001381690.1 COP9 signalosome complex subunit 1 isoform 12
NM_001394762.1 NP_001381691.1 COP9 signalosome complex subunit 1 isoform 13
NM_001394763.1 NP_001381692.1 COP9 signalosome complex subunit 1 isoform 13
NM_001394764.1 NP_001381693.1 COP9 signalosome complex subunit 1 isoform 14
NM_001394765.1 NP_001381694.1 COP9 signalosome complex subunit 1 isoform 15
NM_001394766.1 NP_001381695.1 COP9 signalosome complex subunit 1 isoform 15
NM_001394767.1 NP_001381696.1 COP9 signalosome complex subunit 1 isoform 15
NM_001394768.1 NP_001381697.1 COP9 signalosome complex subunit 1 isoform 16
NM_001394769.1 NP_001381698.1 COP9 signalosome complex subunit 1 isoform 7
NM_001394770.1 NP_001381699.1 COP9 signalosome complex subunit 1 isoform 7
NM_001394771.1 NP_001381700.1 COP9 signalosome complex subunit 1 isoform 7
NM_001394772.1 NP_001381701.1 COP9 signalosome complex subunit 1 isoform 17
NM_001394773.1 NP_001381702.1 COP9 signalosome complex subunit 1 isoform 17
NM_001394774.1 NP_001381703.1 COP9 signalosome complex subunit 1 isoform 18
NM_001394775.1 NP_001381704.1 COP9 signalosome complex subunit 1 isoform 19
NM_001394776.1 NP_001381705.1 COP9 signalosome complex subunit 1 isoform 20
NM_001394777.1 NP_001381706.1 COP9 signalosome complex subunit 1 isoform 21
NM_004127.7 NP_004118.3 COP9 signalosome complex subunit 1 isoform 2
NM_212492.4 NP_997657.1 COP9 signalosome complex subunit 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17337451 GOA
Biological Process GO Annotation Evidence References Source
involved in protein deneddylation IDA
IDA: Inferred from direct assay
19141280 GOA
Cellular Component GO Annotation Evidence References Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
18850735 GOA
part of COP9 signalosome IPI
IPI: Inferred from physical interaction
25043011 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
24421388 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24421388 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPS1 Protein Structure

RPN7

RPN7: 26S proteasome subunit RPN7 (127 - 308)

PCI

PCI: PCI domain (324 - 426)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
Protein Preferred Names Protein Names

COP9 signalosome complex subunit 1

  • JAB1-containing signalosome subunit 1

GPS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPS1 Q13098 COPS5 Homo sapiens Q92905
TEM
27029275
Intra
GPS1 Q13098 COPS5 Homo sapiens Q92905
Anti Tag CoIP
33961781
Intra
GPS1 Q13098 COPS5 Homo sapiens Q92905
EM
20399188
Intra
GPS1 Q13098 COPS5 Homo sapiens Q92905
GMS
20399188
Intra
GPS1 Q13098 COPS5 Homo sapiens Q92905
Anti Bait CoIP
19444310
Intra
GPS1 Q13098 COPS5 Homo sapiens Q92905
3D-EM
27029275
Intra
GPS1 Q13098 COPS5 Homo sapiens Q92905
X-Ray Diffraction
27029275
Intra
GPS1 Q13098 COPS5 Homo sapiens Q92905
Solution Sedimentation
24421388
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Xeroderma Pigmentosum, Complementation Group E

  • Xeroderma Pigmentosum V

  • Xp5

  • Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype

  • Xpe

  • Xp, Group E

  • Xeroderma Pigmentosum, Type 5

  • Xeroderma Pigmentosum Complementation Group E

  • XP-E

  • Xp Group E
Corneal Dystrophy, Avellino Type

  • Avellino Corneal Dystrophy

  • CDA

  • Combined Granular-Lattice Corneal Dystrophy

  • Cgd2

  • Granular Corneal Dystrophy Type 2

  • Acd

  • Granular Corneal Dystrophy 2

  • Corneal Dystrophy Avellino Type

  • Granular Corneal Dystrophy Type Ii

  • Granular Corneal Dystrophy, Type Ii

  • Combined Granular-Lattice Corneal Dystrophies

  • Granular And Lattice Corneal Dystrophies

  • Granular-Lattice Corneal Dystrophy

  • Gcd2

  • Gcdii

  • Granular-Lattice Corneal Dystrophy
Granular Corneal Dystrophy

  • Granular Dystrophy Corneal

  • Corneal Dystrophies, Hereditary

  • Hereditary Corneal Dystrophy

  • Corneal Dystrophy Nos

  • Familial Hereditary Corneal Degeneration

  • Hereditary Corneal Opacity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05757 GPS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19903 Gps1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26404 Gps1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GPS1 RGD RGD:621532
Macaca mulatta GPS1 VGNC VGNC:73149
Mus musculus GPS1 MGD MGI:2384801
Canis familiaris GPS1 VGNC VGNC:41455
Felis catus GPS1 VGNC VGNC:67450
Bos taurus GPS1 VGNC VGNC:29612
Others GPS1 NCBI