Hlcs - holocarboxylase synthetase Gene

Also Known as RGD1565360

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 288240

Summary

Enables biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase activity and identical protein binding activity. Involved in response to biotin. Predicted to be located in chromatin; cytosol; and nuclear periphery. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase). [provided by Alliance of Genome Resources, Apr 2022]

Hlcs Products (8)

mRNA Protein Name
XM_039088792.1 XP_038944720.1 biotin--protein ligase isoform X2
XM_039088794.1 XP_038944722.1 biotin--protein ligase isoform X1
XM_039088791.1 XP_038944719.1 biotin--protein ligase isoform X1
XM_039088797.1 XP_038944725.1 biotin--protein ligase isoform X1
XM_039088798.1 XP_038944726.1 biotin--protein ligase isoform X1
XM_039088796.1 XP_038944724.1 biotin--protein ligase isoform X1
XM_039088795.1 XP_038944723.1 biotin--protein ligase isoform X4
XM_039088793.1 XP_038944721.1 biotin--protein ligase isoform X3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables biotin--[biotin carboxyl-carrier protein] ligase activity IDA
IDA: Inferred from direct assay
7849632 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
7849632 RGD
Biological Process GO Annotation Evidence References Source
involved in response to biotin IEP
IEP: Inferred from expression pattern
16359899 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

biotin--protein ligase

  • holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)

  • holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)

  • holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxyl

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12564 Phthalazinone pyrazole Inhibitor 98.0% Unkown
HY-183354 HLC40 / Unkown
HY-RS06218 HLCS Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hlcs NCBI NCBI:3141