Nuak2 - NUAK family kinase 2 Gene

Also Known as Snark; UV126; 1200013b22rik

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 289419

About Nuak2

Primary_assembly 13: 43,753,832-43,770,604 forward strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 213 orthologues, 26 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 251.3), Adrenal (RPKM 38.5) and 6 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in cellular response to glucose starvation and protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Nuak2 Products (2)

mRNA Protein Name
NM_001007617.1 NP_001007618.1 NUAK family SNF1-like kinase 2
NM_001007617.1 NP_001007618.1 NUAK family SNF1-like kinase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
11284715 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
11284715 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11284715 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
15893879 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11284715 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nuak2 Protein Structure

PKc_like

PKc_like: cl21453 (52 - 306)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 630 a.a.
Protein Preferred Names Protein Names

NUAK family SNF1-like kinase 2

  • NUAK family, SNF1-like kinase, 2

  • SNF1MP kinase-related kinase

  • SNF1MP-activated protein kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15802 WZ4003 Inhibitor 98.22% Unkown
HY-120877 MRT199665 Inhibitor 99.85% Unkown
HY-156397 HTH-02-006 Inhibitor 99.42% Unkown
HY-182743 OICR19451 Inhibitor / Unkown
HY-182361 NUAK1-IN-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nuak2 NCBI NCBI:81788