Bsn - bassoon (presynaptic cytomatrix protein) Gene

Rattus norvegicus

Also known as Znf231

Gene ID: 29138 | Gene type: protein coding

About Bsn

Summary

Enables dynein light chain binding activity and transcription corepressor binding activity. Involved in presynaptic active zone assembly; regulation of ubiquitin protein Ligase activity; and retrograde axonal transport. Located in several cellular components, including axon cytoplasm; cytoplasmic vesicle; and Cytoskeleton of presynaptic active zone. Is extrinsic component of membrane. Is active in several cellular components, including GABA-ergic synapse; hippocampal mossy fiber to CA3 synapse; and presynaptic active zone cytoplasmic component. Colocalizes with synaptic membrane. Orthologous to human BSN (bassoon presynaptic cytomatrix protein). [provided by Alliance of Genome Resources, Apr 2022]

Bsn Products(1)

mRNA	Protein	Name
NM_019146.2	NP_062019.2	protein bassoon

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dynein light chain binding	IPI IPI: Inferred from physical interaction	19380881	RGD
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	21700703	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12163476	RGD
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	25652077	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axo-dendritic transport	IDA IDA: Inferred from direct assay	19380881	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	21700703	RGD
involved in presynaptic active zone assembly	IDA IDA: Inferred from direct assay	22875941	RGD
involved in regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	23403927	RGD
involved in retrograde axonal transport	IDA IDA: Inferred from direct assay	19380881	RGD
involved in synapse organization	IDA IDA: Inferred from direct assay	23403927	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	10340516	RGD
located in Golgi-associated vesicle	IDA IDA: Inferred from direct assay	22875941	RGD
located in axon cytoplasm	IDA IDA: Inferred from direct assay	19380881	RGD
located in cell cortex	IDA IDA: Inferred from direct assay	19380881	RGD
located in cytoskeleton of presynaptic active zone	IDA IDA: Inferred from direct assay	9679147	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	19730411	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9679147	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	9679147	RGD
located in inhibitory synapse	IDA IDA: Inferred from direct assay	11596050	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16373352	RGD
located in piccolo-bassoon transport vesicle	IDA IDA: Inferred from direct assay	19380881	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	15978582	RGD
is active in presynaptic active zone cytoplasmic component	IDA IDA: Inferred from direct assay	9679147	RGD
located in ribbon synapse	IDA IDA: Inferred from direct assay	11596050	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	19380881	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	26212709	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	16373352	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein bassoon

neuronal double zinc finger protein

zinc finger protein 231

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114591	Spiromesifen	Inhibitor	99.42%	Unkown
HY-114591S	Spiromesifen-d9		/	Unkown
HY-RS01644	BSN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bsn	NCBI	NCBI:8927

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